LYRIC (MTDH) (NM_178812) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207238L2V

Lenti ORF particles, MTDH (mGFP-tagged) - Human metadherin (MTDH), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: LYRIC
• Synonyms: 3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_178812
• ORF Size: 1746 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207238).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_178812.2, NP_848927.1
• RefSeq Size: 7667 bp
• RefSeq ORF: 1749 bp
• Locus ID: 92140
• UniProt ID: Q86UE4
• Cytogenetics: 8q22.1
• Protein Families: Transmembrane
• MW: 63.8 kDa
• Gene Summary: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.[UniProtKB/Swiss-Prot Function]