PARN (NM_002582) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207220L4V

Lenti ORF particles, PARN (mGFP-tagged) - Human poly(A)-specific ribonuclease (deadenylation nuclease) (PARN), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PARN
• Synonyms: DAN; DKCB6; PFBMFT4
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_002582
• ORF Size: 1917 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207220).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002582.1
• RefSeq Size: 3083 bp
• RefSeq ORF: 1920 bp
• Locus ID: 5073
• UniProt ID: O95453
• Cytogenetics: 16p13.12
• Domains: R3H, CAF1
• Protein Families: Transcription Factors
• Protein Pathways: RNA degradation
• MW: 73.5 kDa
• Gene Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]