IL10RA (NM_001558) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207020L2V

Lenti ORF particles, IL10RA (mGFP-tagged) - Human interleukin 10 receptor, alpha (IL10RA), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: IL10RA
• Synonyms: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_001558
• ORF Size: 1734 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207020).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001558.2
• RefSeq Size: 3649 bp
• RefSeq ORF: 1737 bp
• Locus ID: 3587
• UniProt ID: Q13651
• Cytogenetics: 11q23.3
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• MW: 62.9 kDa
• Gene Summary: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]