GABARAPL2 (NM_007285) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC206950L3V

Lenti ORF particles, GABARAPL2 (Myc-DDK tagged) - Human GABA(A) receptor-associated protein-like 2 (GABARAPL2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: GABARAPL2
• Synonyms: ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_007285
• ORF Size: 351 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC206950).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_007285.5
• RefSeq Size: 450 bp
• RefSeq ORF: 354 bp
• Locus ID: 11345
• UniProt ID: P60520
• Cytogenetics: 16q23.1
• Domains: MAP1_LC3
• Protein Pathways: Regulation of autophagy
• MW: 13.5 kDa
• Gene Summary: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.[UniProtKB/Swiss-Prot Function]