FRS2 (NM_006654) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC205842L3V

Lenti ORF particles, FRS2 (Myc-DDK tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: FRS2
• Synonyms: FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_006654
• ORF Size: 1536 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205842).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006654.3, NP_006645.2
• RefSeq Size: 6883 bp
• RefSeq ORF: 1527 bp
• Locus ID: 10818
• UniProt ID: Q8WU20
• Cytogenetics: 12q15
• Domains: IRS
• Protein Families: Druggable Genome
• Protein Pathways: Neurotrophin signaling pathway
• MW: 57.5 kDa
• Gene Summary: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.[UniProtKB/Swiss-Prot Function]