EFHA1 (MICU2) (NM_152726) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC205455L2V

Lenti ORF particles, EFHA1 (mGFP-tagged)-Human EF-hand domain family, member A1 (EFHA1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MICU2
• Synonyms: 1110008L20Rik; EFHA1
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_152726
• ORF Size: 1302 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205455).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_152726.1
• RefSeq Size: 1891 bp
• RefSeq ORF: 1305 bp
• Locus ID: 221154
• UniProt ID: Q8IYU8
• Cytogenetics: 13q12.11
• Domains: EFh
• MW: 49.5 kDa
• Gene Summary: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).[UniProtKB/Swiss-Prot Function]