PI 3 Kinase Class 3 (PIK3C3) (NM_002647) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC205317L2V

Lenti ORF particles, PIK3C3 (mGFP-tagged) - Human phosphoinositide-3-kinase, class 3 (PIK3C3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PIK3C3
• Synonyms: hVps34; VPS34; Vps34
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_002647
• ORF Size: 2661 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205317).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002647.2
• RefSeq Size: 3083 bp
• RefSeq ORF: 2664 bp
• Locus ID: 5289
• UniProt ID: Q8NEB9
• Cytogenetics: 18q12.3
• Domains: PI3_PI4_kinase, PI3Ka, PI3K_C2
• Protein Families: Druggable Genome
• Protein Pathways: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of autophagy
• MW: 101.4 kDa
• Gene Summary: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).[UniProtKB/Swiss-Prot Function]