XRCC1 (NM_006297) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204952L4V

Lenti ORF particles, XRCC1 (mGFP-tagged) - Human X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: XRCC1
• Synonyms: RCC; SCAR26
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_006297
• ORF Size: 1899 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204952).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006297.1
• RefSeq Size: 2102 bp
• RefSeq ORF: 1902 bp
• Locus ID: 7515
• UniProt ID: P18887
• Cytogenetics: 19q13.31
• Domains: BRCT, XRCC1_N
• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair
• MW: 69.5 kDa
• Gene Summary: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]