Vinculin (VCL) (NM_003373) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204576L3V

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  • LentiORF®

Lenti ORF particles, VCL (Myc-DDK tagged) - Human vinculin (VCL), transcript variant 2, 200ul, >10^7 TU/mL



USD 1,942.00


Availability*
6 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol VCL
Synonyms CMD1W; CMH15; HEL114; MV; MVCL
Mammalian Cell Selection Puromycin
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN NM_003373
ORF Size 3198 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC204576).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_003373.3
RefSeq Size 5443 bp
RefSeq ORF 3201 bp
Locus ID 7414
UniProt ID P18206
Cytogenetics 10q22.2
Domains Vinculin
Protein Families Druggable Genome
Protein Pathways Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
MW 116.7 kDa
Gene Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
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