SETDB1 (NM_012432) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC203647L4V

Lenti ORF particles, SETDB1 (mGFP-tagged) - Human SET domain, bifurcated 1 (SETDB1), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: SETDB1
• Synonyms: ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_012432
• ORF Size: 3870 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC203647).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_012432.2, NP_036564.2
• RefSeq Size: 4446 bp
• RefSeq ORF: 3873 bp
• Locus ID: 9869
• UniProt ID: Q15047
• Cytogenetics: 1q21.3
• Domains: SET, MBD, TUDOR, PreSET, Pre-SET
• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation
• MW: 143 kDa
• Gene Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]