Cofilin 1 (CFL1) (NM_005507) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC203585L4V
- LentiORF®
Lenti ORF particles, CFL1 (mGFP-tagged) - Human cofilin 1 (non-muscle) (CFL1), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK DDK w/ Puro mGFP
AAV Particle: DDK
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USD 365.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | Cofilin 1 |
Synonyms | CFL; cofilin; HEL-S-15 |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_005507 |
ORF Size | 498 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC203585).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_005507.2 |
RefSeq Size | 1260 bp |
RefSeq ORF | 501 bp |
Locus ID | 1072 |
UniProt ID | P23528 |
Cytogenetics | 11q13.1 |
Domains | ADF |
Protein Families | Druggable Genome |
Protein Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |
MW | 18.5 kDa |
Gene Summary | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] |
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