IMPDH2 (NM_000884) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC202977L2V

Lenti ORF particles, IMPDH2 (mGFP-tagged) - Human IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: IMPDH2
• Synonyms: IMPD2; IMPDH-II
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000884
• ORF Size: 1542 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202977).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000884.2
• RefSeq Size: 1712 bp
• RefSeq ORF: 1545 bp
• Locus ID: 3615
• UniProt ID: P12268
• Cytogenetics: 3p21.31
• Domains: CBS, IMPDH
• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism
• MW: 55.8 kDa
• Gene Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]