QPRT (NM_014298) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC202960L2V

Lenti ORF particles, QPRT (mGFP-tagged) - Human quinolinate phosphoribosyltransferase (QPRT), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: QPRT
• Synonyms: HEL-S-90n; QPRTase
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_014298
• ORF Size: 891 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202960).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_014298.3
• RefSeq Size: 1575 bp
• RefSeq ORF: 894 bp
• Locus ID: 23475
• UniProt ID: Q15274
• Cytogenetics: 16p11.2
• Domains: QRPTase
• Protein Pathways: Metabolic pathways, Nicotinate and nicotinamide metabolism
• MW: 30.8 kDa
• Gene Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]