Nuclear Factor Erythroid Derived 2 (NFE2) (NM_006163) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC202924L3V

Lenti ORF particles, NFE2 (Myc-DDK tagged) - Human nuclear factor (erythroid-derived 2), 45kDa (NFE2), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Nuclear Factor Erythroid Derived 2
• Synonyms: NF-E2; p45
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_006163
• ORF Size: 1119 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202924).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006163.1
• RefSeq Size: 1697 bp
• RefSeq ORF: 1122 bp
• Locus ID: 4778
• UniProt ID: Q16621
• Cytogenetics: 12q13.13
• Protein Families: Transcription Factors
• MW: 41.5 kDa
• Gene Summary: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.[UniProtKB/Swiss-Prot Function]