GTP cyclohydrolase 1 (GCH1) (NM_000161) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC202893L3V

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  • LentiORF®

Lenti ORF particles, GCH1 (Myc-DDK tagged) - Human GTP cyclohydrolase 1 (GCH1), transcript variant 1, 200ul, >10^7 TU/mL



USD 1,020.00


Availability*
3 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol GCH1
Synonyms DYT5; DYT5a; DYT14; GCH; GTP-CH-1; GTPCH1; HPABH4B
Mammalian Cell Selection Puromycin
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN NM_000161
ORF Size 753 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC202893).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_000161.2
RefSeq Size 2941 bp
RefSeq ORF 753 bp
Locus ID 2643
UniProt ID P30793
Cytogenetics 14q22.2
Domains GTP_cyclohydroI
Protein Families Druggable Genome
Protein Pathways Folate biosynthesis, Metabolic pathways
MW 27.9 kDa
Gene Summary This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
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