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UBP43 (USP18) (NM_017414) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC202374L2V
- LentiORF®
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Lenti ORF particles, USP18 (mGFP-tagged) - Human ubiquitin specific peptidase 18 (USP18), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK DDK w/ Puro mGFP w/ Puro
AAV Particle: DDK
Buy this product and get 50% off on the Lenti RapidTiter kit. Use Code: Rapid50
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USD 365.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone Lentiviral Particle |
| Tag | mGFP |
| Symbol | UBP43 |
| Synonyms | ISG43; PTORCH2; UBP43 |
| Mammalian Cell Selection | None |
| Vector | pLenti-C-mGFP |
| ACCN | NM_017414 |
| ORF Size | 1116 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC202374).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_017414.2 |
| RefSeq Size | 2037 bp |
| RefSeq ORF | 1119 bp |
| Locus ID | 11274 |
| UniProt ID | Q9UMW8 |
| Cytogenetics | 22q11.21 |
| Domains | UCH |
| Protein Families | Druggable Genome, Protease |
| MW | 43 kDa |
| Gene Summary | The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011] |
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