TIMP1 (NM_003254) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201548L1V

Lenti ORF particles, TIMP1 (Myc-DDK tagged) - Human TIMP metallopeptidase inhibitor 1 (TIMP1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: TIMP1
• Synonyms: CLGI; EPA; EPO; HCI; TIMP; TIMP-1
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_003254
• ORF Size: 621 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC201548).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003254.2
• RefSeq Size: 931 bp
• RefSeq ORF: 624 bp
• Locus ID: 7076
• UniProt ID: P01033
• Cytogenetics: Xp11.3
• Domains: NTR
• Protein Families: Druggable Genome, Secreted Protein
• MW: 23.2 kDa
• Gene Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]