EIF4EL3 (EIF4E2) (NM_004846) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201391L2V

Lenti ORF particles, EIF4E2 (mGFP-tagged) - Human eukaryotic translation initiation factor 4E family member 2 (EIF4E2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: EIF4EL3
• Synonyms: 4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_004846
• ORF Size: 735 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC201391).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004846.2
• RefSeq Size: 1078 bp
• RefSeq ORF: 738 bp
• Locus ID: 9470
• UniProt ID: O60573
• Cytogenetics: 2q37.1
• Domains: IF4E
• Protein Families: Transcription Factors
• Protein Pathways: Insulin signaling pathway, mTOR signaling pathway
• MW: 28.4 kDa
• Gene Summary: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB/Swiss-Prot Function]