Bak (BAK1) (NM_001188) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201216L4V

Lenti ORF particles, BAK1 (mGFP-tagged) - Human BCL2-antagonist/killer 1 (BAK1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Bak
• Synonyms: BAK; BAK-LIKE; BCL2L7; CDN1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_001188
• ORF Size: 633 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC201216).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001188.2
• RefSeq Size: 2203 bp
• RefSeq ORF: 636 bp
• Locus ID: 578
• UniProt ID: Q16611
• Cytogenetics: 6p21.31
• Domains: Bcl-2
• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transmembrane
• MW: 23.4 kDa
• Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]