TRIM56 (NM_030961) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200891L3V

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  • LentiORF®

Lenti ORF particles, TRIM56 (Myc-DDK tagged) - Human tripartite motif containing 56 (TRIM56), 200ul, >10^7 TU/mL



USD 1,241.00


Availability*
2 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol TRIM56
Synonyms RNF109
Mammalian Cell Selection Puromycin
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN NM_030961
ORF Size 2265 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC200891).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_030961.1
RefSeq Size 3547 bp
RefSeq ORF 2268 bp
Locus ID 81844
UniProt ID Q9BRZ2
Cytogenetics 7q22.1
MW 81.3 kDa
Gene Summary E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).[UniProtKB/Swiss-Prot Function]
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