EIF5A (NM_001970) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200770L2V

Lenti ORF particles, EIF5A (mGFP-tagged) - Human eukaryotic translation initiation factor 5A (EIF5A), transcript variant B, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: EIF5A
• Synonyms: eIF-4D; EIF-5A; EIF5A1; eIF5AI
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_001970
• ORF Size: 462 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200770).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001970.3
• RefSeq Size: 1355 bp
• RefSeq ORF: 465 bp
• Locus ID: 1984
• UniProt ID: P63241
• Cytogenetics: 17p13.1
• Domains: eIF-5a, KOW
• MW: 16.8 kDa
• Gene Summary: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.[UniProtKB/Swiss-Prot Function]