Superoxide Dismutase 1 (SOD1) (NM_000454) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200725L1V

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  • LentiORF®

Lenti ORF particles, SOD1 (Myc-DDK tagged) - Human superoxide dismutase 1, soluble (SOD1), 200ul, >10^7 TU/mL



Get anti-DDK tag antibody at $68 with code “DDK”. View details.

USD 1,020.00


Availability*
3 Weeks

Size
    • 200 ul


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Specifications

Product Data
Product Name Superoxide Dismutase 1 (SOD1) (NM_000454) Human Tagged ORF Clone Lentiviral Particle
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol SOD1
Synonyms ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD; STAHP
Vector pLenti-C-Myc-DDK
ACCN NM_000454
ORF Size 462 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC200725).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_000454.4, NP_000445.1
RefSeq Size 981 bp
RefSeq ORF 465 bp
Locus ID 6647
UniProt ID P00441, V9HWC9
Cytogenetics 21q22.11
Domains sodcu
Protein Families Druggable Genome
Protein Pathways Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases
MW 15.9 kDa
Gene Summary The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]
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