DUSP4 (NM_001394) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200640L4V

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  • LentiORF®

Lenti ORF particles, DUSP4 (mGFP-tagged) - Human dual specificity phosphatase 4 (DUSP4), transcript variant 1, 200ul, >10^7 TU/mL



USD 1,020.00


Availability*
3 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol DUSP4
Synonyms HVH2; MKP-2; MKP2; TYP
Mammalian Cell Selection Puromycin
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001394
ORF Size 1182 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC200640).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001394.5
RefSeq Size 5625 bp
RefSeq ORF 1185 bp
Locus ID 1846
UniProt ID Q13115
Cytogenetics 8p12
Domains DSPc, RHOD, PTPc_motif
Protein Families Phosphatase
Protein Pathways MAPK signaling pathway
MW 43 kDa
Gene Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
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