MAN2B1 (NM_000528) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200638L2V

Lenti ORF particles, MAN2B1 (mGFP-tagged) - Human mannosidase, alpha, class 2B, member 1 (MAN2B1), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MAN2B1
• Synonyms: LAMAN; MANB
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000528
• ORF Size: 3033 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200638).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000528.2
• RefSeq Size: 3231 bp
• RefSeq ORF: 3036 bp
• Locus ID: 4125
• UniProt ID: O00754
• Cytogenetics: 19p13.13
• Domains: Glyco_hydro_38
• Protein Families: Druggable Genome
• Protein Pathways: Lysosome, Other glycan degradation
• MW: 113.7 kDa
• Gene Summary: This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]