FLIP (CFLAR) (NM_003879) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200608L3V

Lenti ORF particles, CFLAR (Myc-DDK tagged) - Human CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC200608L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC200608L3V particle to overexpress human CFLAR-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: CFLAR
• Synonyms: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_003879
• ORF Size: 1440 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200608).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003879.3
• RefSeq Size: 10640 bp
• RefSeq ORF: 1443 bp
• Locus ID: 8837
• UniProt ID: O15519
• Cytogenetics: 2q33.1
• Domains: DED, CASc, ICE_p20
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Apoptosis
• MW: 55.3 kDa
• Gene Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]