HDAC3 (NM_003883) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200605L3V

Lenti ORF particles, HDAC3 (Myc-DDK tagged) - Human histone deacetylase 3 (HDAC3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: HDAC3
• Synonyms: HD3; KDAC3; RPD3; RPD3-2
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_003883
• ORF Size: 1284 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200605).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003883.2, NP_003874.2
• RefSeq Size: 1965 bp
• RefSeq ORF: 1287 bp
• Locus ID: 8841
• UniProt ID: O15379
• Cytogenetics: 5q31.3
• Domains: Hist_deacetyl
• Protein Families: Druggable Genome, Transcription Factors
• MW: 48.8 kDa
• Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]