PLCG 2 (PLCG2) (NM_002661) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200442L3V

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  • LentiORF®

Lenti ORF particles, PLCG2 (Myc-DDK tagged) - Human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), 200ul, >10^7 TU/mL


Product Datasheet for 'RC200442L3V'


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USD 1,540.00


Availability*
5 Weeks

Size
    • 200 ul


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Specifications

Product Data
Product Name PLCG 2 (PLCG2) (NM_002661) Human Tagged ORF Clone Lentiviral Particle
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol PLCG2
Synonyms APLAID; FCAS3; PLC-gamma-2; PLC-IV
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
ACCN NM_002661
ORF Size 3795 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC200442).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_002661.2, NP_002652.2
RefSeq Size 8707 bp
RefSeq ORF 3798 bp
Locus ID 5336
Cytogenetics 16q23.3
Domains C2, PI-PLC-X, SH2, SH3, PI-PLC-Y, PH
Protein Families Druggable Genome
Protein Pathways B cell receptor signaling pathway, Calcium signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glioma, Inositol phosphate metabolism, Leukocyte transendothelial migration, Metabolic pathways, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Phosphatidylinositol signaling system, VEGF signaling pathway, Vibrio cholerae infection
MW 147.9 kDa
Gene Summary The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
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