SYK (NM_003177) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200413L1V

Lenti ORF particles, SYK (Myc-DDK tagged) - Human spleen tyrosine kinase (SYK), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC200413L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC200413L1V particle to overexpress human SYK-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: SYK
• Synonyms: IMD82; p72-Syk
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_003177
• ORF Size: 1905 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200413).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003177.3, NP_003168.2
• RefSeq Size: 2672 bp
• RefSeq ORF: 1908 bp
• Locus ID: 6850
• UniProt ID: P43405
• Cytogenetics: 9q22.2
• Domains: pkinase, SH2, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity
• MW: 71.9 kDa
• Gene Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]