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INSIG1 (NM_005542) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC200312L4V
- LentiORF®
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Lenti ORF particles, INSIG1 (mGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 1, 200ul, >10^7 TU/mL
Lentiviral Particles: DDK DDK w/ Puro mGFP
AAV Particle: DDK
Buy this product and get 50% off on the Lenti RapidTiter kit. Use Code: Rapid50
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USD 365.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone Lentiviral Particle |
| Tag | mGFP |
| Symbol | INSIG1 |
| Synonyms | CL6 |
| Mammalian Cell Selection | Puromycin |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_005542 |
| ORF Size | 831 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200312).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005542.3 |
| RefSeq Size | 3020 bp |
| RefSeq ORF | 834 bp |
| Locus ID | 3638 |
| UniProt ID | O15503 |
| Cytogenetics | 7q36.3 |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 30 kDa |
| Gene Summary | This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] |
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