Dnajb2 (NM_178055) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR222471L4V

Lenti ORF particles, Dnajb2 (GFP-tagged) - Mouse DnaJ (Hsp40) homolog, subfamily B, member 2 (Dnajb2), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Dnajb2
• Synonyms: 2700059H22Rik; Dnajb10; Hsj1; mDj8
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_178055
• ORF Size: 834 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR222471).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_178055.4, NP_835156.1
• RefSeq Size: 1935 bp
• RefSeq ORF: 834 bp
• Locus ID: 56812
• UniProt ID: Q9QYI5
• Cytogenetics: 1 C4
• Gene Summary: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.[UniProtKB/Swiss-Prot Function]