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Arhgef5 (NM_133674) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR215297L1V
- LentiORF®
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Lenti ORF particles, Arhgef5 (Myc-DDK-tagged) - Mouse Rho guanine nucleotide exchange factor (GEF) 5 (Arhgef5), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro mGFP mGFP w/ Puro
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USD 365.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone Lentiviral Particle |
| Tag | Myc-DDK |
| Symbol | Arhgef5 |
| Synonyms | 2210412D05Rik; AA717842; AW495314; Tim1 |
| Mammalian Cell Selection | None |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_133674 |
| ORF Size | 4743 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR215297).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133674.1, NP_598435.1 |
| RefSeq Size | 5420 bp |
| RefSeq ORF | 4746 bp |
| Locus ID | 54324 |
| UniProt ID | E9Q7D5 |
| Cytogenetics | 6 B2.1 |
| Gene Summary | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:19713215, PubMed:21525037). Strongly activates RHOA (PubMed:19713215, PubMed:21525037). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (PubMed:19713215). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:21525037). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation (PubMed:21525037). Involved in positive regulation of immature dendritic cell migration (PubMed:19713215).[UniProtKB/Swiss-Prot Function] |
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