OriGene Logo

Irf3 (NM_016849) Mouse Tagged ORF Clone Lentiviral Particle

  • LentiORF®
  • Product Brand Image
Be the first to review this product
SKU
MR206641L4V
Lenti ORF particles, Irf3 (GFP-tagged) - Mouse interferon regulatory factor 3 (Irf3), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
mGFP w/ Puro DDK w/ Puro
  $1,236.00
2 Weeks*
Size
Bulk Requests & Clone Modifications

Frequently Bought Together (2)

TR30038 One-Wash Lentivirus Titer Kit, HIV-1 p24 ELISA 96 reactions
$671.00
PS100093V Lenti ORF control particles of pLenti-C-mGFP-P2A-Puro, 1x10^7 TU/ml, 0.5 ml 500 ul
$365.00

Other products for "Irf3 or NM_016849"

Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Irf3
Synonyms C920001K05Rik; IRF-3
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR206641).
ACCN NM_016849
ORF Size 1257 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_016849.3
RefSeq Size 2041 bp
RefSeq ORF 1260 bp
Locus ID 54131
UniProt ID P70671
Cytogenetics 7 B3
Summary Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:15800576). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15800576). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:16846591, PubMed:16979567, PubMed:20049431). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16846591, PubMed:16979567, PubMed:20049431). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591, PubMed:16979567, PubMed:20049431).[UniProtKB/Swiss-Prot Function]
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Documents
Resources

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.