Cth (NM_145953) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR206244L2V

Lenti ORF particles, Cth (GFP-tagged) - Mouse cystathionase (cystathionine gamma-lyase) (Cth), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Cth
• Synonyms: 0610010I13Rik; AI314617; BC019483; CSE; Cys3
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_145953
• ORF Size: 1197 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR206244).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_145953.2, NP_666065.1
• RefSeq Size: 1815 bp
• RefSeq ORF: 1197 bp
• Locus ID: 107869
• UniProt ID: Q8VCN5
• Cytogenetics: 3 H4
• Gene Summary: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.[UniProtKB/Swiss-Prot Function]