Sfrp1 (NM_013834) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR204470L3V

Lenti ORF particles, Sfrp1 (Myc-DDK-tagged) - Mouse secreted frizzled-related protein 1 (Sfrp1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Sfrp1
• Synonyms: 2210415K03Rik; AW011917; AW107218; AW742929; sFRP-1
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_013834
• ORF Size: 942 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR204470).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_013834.2, NP_038862.2
• RefSeq Size: 4375 bp
• RefSeq ORF: 945 bp
• Locus ID: 20377
• UniProt ID: Q8C4U3
• Cytogenetics: 8 11.48 cM
• Gene Summary: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity).[UniProtKB/Swiss-Prot Function]