Snca (NM_001042451) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR200876L2V

  • LentiORF®

Lenti ORF particles, Snca (GFP-tagged) - Mouse synuclein, alpha (Snca), transcript variant 1, 200ul, >10^7 TU/mL

Lentiviral Particles: DDK DDK w/ Puro mGFP mGFP w/ Puro



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USD 775.00

2 Weeks*

Size
    • 200 ul

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Specifications

Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol Snca
Synonyms alpha-Syn; alphaSYN; NACP
Mammalian Cell Selection None
Vector pLenti-C-mGFP
ACCN NM_001042451
ORF Size 420 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR200876).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001042451.1
RefSeq Size 1296 bp
RefSeq ORF 423 bp
Locus ID 20617
UniProt ID O55042
Cytogenetics 6 29.15 cM
Gene Summary Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).[UniProtKB/Swiss-Prot Function]

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