Activin Receptor Type IA (ACVR1) (NM_001105) Human Untagged Clone

CAT#: SC323384

ACVR1 (untagged)-Kinase deficient mutant (K235M) of Human activin A receptor, type I (ACVR1), transcript variant 1


  "NM_001105" in other vectors (7)

Reconstitution Protocol

USD 712.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol Activin Receptor Type IA
Synonyms ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC323384 sequence for NM_001105 edited (data generated by NextGen Sequencing)
ATGGTAGATGGAGTGATGATTCTTCCTGTGCTTATCATGATTGCTCTCCCCTCCCCTAGT
ATGGAAGATGAGAAGCCCAAGGTCAACCCCAAACTCTACATGTGTGTGTGTGAAGGTCTC
TCCTGCGGTAATGAGGACCACTGTGAAGGCCAGCAGTGCTTTTCCTCACTGAGCATCAAC
GATGGCTTCCACGTCTACCAGAAAGGCTGCTTCCAGGTTTATGAGCAGGGAAAGATGACC
TGTAAGACCCCGCCGTCCCCTGGCCAAGCTGTGGAGTGCTGCCAAGGGGACTGGTGTAAC
AGGAACATCACGGCCCAGCTGCCCACTAAAGGAAAATCCTTCCCTGGAACACAGAATTTC
CACTTGGAGGTTGGCCTCATTATTCTCTCTGTAGTGTTCGCAGTATGTCTTTTAGCCTGC
CTGCTGGGAGTTGCTCTCCGAAAATTTAAAAGGCGCAACCAAGAACGCCTCAATCCCCGA
GACGTGGAGTATGGCACTATCGAAGGGCTCATCACCACCAATGTTGGAGACAGCACTTTA
GCAGATTTATTGGATCATTCGTGTACATCAGGAAGTGGCTCTGGTCTTCCTTTTCTGGTA
CAAAGAACAGTGGCTCGCCAGATTACACTGTTGGAGTGTGTCGGGAAAGGCAGGTATGGT
GAGGTGTGGAGGGGCAGCTGGCAAGGGGAGAATGTTGCCGTGATGATCTTCTCCTCCCGT
GATGAGAAGTCATGGTTCAGGGAAACGGAATTGTACAACACTGTGATGCTGAGGCATGAA
AATATCTTAGGTTTCATTGCTTCAGACATGACATCAAGACACTCCAGTACCCAGCTGTGG
TTAATTACACATTATCATGAAATGGGATCGTTGTACGACTATCTTCAGCTTACTACTCTG
GATACAGTTAGCTGCCTTCGAATAGTGCTGTCCATAGCTAGTGGTCTTGCACATTTGCAC
ATAGAGATATTTGGGACCCAAGGGAAACCAGCCATTGCCCATCGAGATTTAAAGAGCAAA
AATATTCTGGTTAAGAAGAATGGACAGTGTTGCATAGCAGATTTGGGCCTGGCAGTCATG
CATTCCCAGAGCACCAATCAGCTTGATGTGGGGAACAATCCCCGTGTGGGCACCAAGCGC
TACATGGCCCCCGAAGTTCTAGATGAAACCATCCAGGTGGATTGTTTCGATTCTTATAAA
AGGGTCGATATTTGGGCCTTTGGACTTGTTTTGTGGGAAGTGGCCAGGCGGATGGTGAGC
AATGGTATAGTGGAGGATTACAAGCCACCGTTCTACGATGTGGTTCCCAATGACCCAAGT
TTTGAAGATATGAGGAAGGTAGTCTGTGTGGATCAACAAAGGCCAAACATACCCAACAGA
TGGTTCTCAGACCCGACATTAACCTCTCTGGCCAAGCTAATGAAAGAATGCTGGTATCAA
AATCCATCCGCAAGACTCACAGCACTGCGTATCAAAAAGACTTTGACCAAAATTGATAAT
TCCCTCGACAAATTGAAAACTGACTGTTGA

Clone variation with respect to NM_001105.4
270 c=>t;704 a=>t
>OriGene 5' read for mutant NM_001105 unedited
ACCGCCCGTCTCAGCAACGGGCGGTAGGCGCTGAACGGTTGGGAGGCTCTATATAAGCAGAGCCTCGTTT
AGTGAACCGTCAGAATCTTGTAATACGACCCACCATAGGGCGGCCGCGAACCCGGCACGAGGGCGTGGAG
CGGGGGACTCAGCCTGGAGCATCGGTAAGCGACACACTGCCAAAGAGAGAGCTGCCGGAGAACTCATAAT
CCCAGGAACGCCTCTTTCTACTCTCCGAGTACCCCAGTGACCAGAGTGAGAGAAGCTCTGAACGAGGGCA
CGCGGCTTGAAGGACTGTGGGGCAGATGTGACCAAGAGCCTGCATTAAGTCTGTACAATGGGTAGATGGA
GTGATGATTTCTTTCCTGTGCTTATCATGATTGCTCTCCCCTCCCCTAGTATGGAAGATGAAAAGCCCCA
GGTCACCCCCAACTTCTCATGTGTGTGGTGTGAAGGTCTCTCCTGCGGTATGAAGACCCACTTGGAGGCA
GCAGTTGCTTTTTCTTAACTGGACCTCAACGATGCCTCCACGTTTACCAAAAAGCTTGCTTCCAGTTTTT
AAACCAGGAAAATAGACTGGAAGACCCGCCTTCCCCTGCCCAACTGTGGATGCGTGCCAAGGGAACGTGT
ACACGGAATATAGGCAATCGCCCTTAAGAGAAACCTCTCCTGACACCAAATTCCATTGAGAGTGGCCATA
TATCCTCGATGTGCCAATATGCTTACCGCGCGGAATGCCTCCGAATTAAGGCACCAAGCTAATCCGACTG
GAATGGCATTCAAGCTTACCATGGACCTTACAATGTATCGTCAGATGCCCGTCCTGGGCAGACCTGTCAA
TCGTGATTGAAAA
>SC323384 kinase domain raw sequence. By performing BLASTX analysis with this sequence against NCBI refernce protein database, you can confirm the presence of the kinase-deficient mutation
ASCAAATAMCTGTTGGAGTGTGTCGGGAAGGCAGGTATGGTGAGGTGTGGAGGGGCAGCTGGCAAGGGGA
GAATGTTGCCGTGATGATCTTCTCCTCCCGTGATGAGAATGTTGCCGTGATGATCTTCTCCTCCCGTGAT
GAGAAGTCATGGTTCAGGGAAACGGAATTGTACAACACTGTGATGCTGAGGCATGAAAATATCTTAGGTT
TCATTGCTTCAGACATGACATCAAGACACTCCAGTACCCAGCTGT
Restriction Sites Please inquire     
ACCN NM_001105
Insert Size 3000 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001105.2, NP_001096.1
RefSeq Size 2952 bp
RefSeq ORF 1530 bp
Locus ID 90
UniProt ID Q04771
Cytogenetics 2q24.1
Domains Activin_recp, pkinase, TyrKc, S_TKc, GS
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
Gene Summary Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.

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