Bonzo (CXCR6) (NM_006564) Human Untagged Clone

CAT#: SC321785

CXCR6 (untagged)-Human chemokine (C-X-C motif) receptor 6 (CXCR6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Bonzo
• Synonyms: BONZO; CD186; CDw186; STRL33; TYMSTR
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006564.1 CATCTCTGCTGGTGTTCATCAGAACAGACACCATGGCAGAGCATGATTACCATGAAGACT
  ATGGGTTCAGCAGTTTCAATGACAGCAGCCAGGAGGAGCATCAAGACTTCCTGCAGTTCA
  GCAAGGTCTTTCTGCCCTGCATGTACCTGGTGGTGTTTGTCTGTGGTCTGGTGGGGAACT
  CTCTGGTGCTGGTCATATCCATCTTCTACCATAAGTTGCAGAGCCTGACGGATGTGTTCC
  TGGTGAACCTACCCCTGGCTGACCTGGTGTTTGTCTGCACTCTGCCCTTCTGGGCCTATG
  CAGGCATCCATGAATGGGTGTTTGGCCAGGTCATGTGCAAGAGCCTACTGGGCATCTACA
  CTATTAACTTCTACACGTCCATGCTCATCCTCACCTGCATCACTGTGGATCGTTTCATTG
  TAGTGGTTAAGGCCACCAAGGCCTACAACCAGCAAGCCAAGAGGATGACCTGGGGCAAGG
  TCACCAGCTTGCTCATCTGGGTGATATCCCTGCTGGTTTCCTTGCCCCAAATTATCTATG
  GCAATGTCTTTAATCTCGACAAGCTCATATGTGGTTACCATGACGAGGCAATTTCCACTG
  TGGTTCTTGCCACCCAGATGACACTGGGGTTCTTCTTGCCACTGCTCACCATGATTGTCT
  GCTATTCAGTCATAATCAAAACACTGCTTCATGCTGGAGGCTTCCAGAAGCACAGATCTC
  TAAAGATCATCTTCCTGGTGATGGCTGTGTTCCTGCTGACCCAGATGCCCTTCAACCTCA
  TGAAGTTCATCCGCAGCACACACTGGGAATACTATGCCATGACCAGCTTTCACTACACCA
  TCATGGTGACAGAGGCCATCGCATACCTGAGGGCCTGCCTTAACCCTGTGCTCTATGCCT
  TTGTCAGCCTGAAGTTTCGAAAGAACTTCTGGAAACTTGTGAAGGACATTGGTTGCCTCC
  CTTACCTTGGGGTCTCACATCAATGGAAATCTTCTGAGGACAATTCCAAGACTTTTTCTG
  CCTCCCACAATGTGGAGGCCACCAGCATGTTCCAGTTATAGGCCTTGCCAGGGTTTCGAG
  AAGCTGCTCTGGAATTTGCAAGGCATGGCTGTGCCCTCTTGATGTGGTGAGGCAGGCTTT
  GTTTATAGCTTGCGCATTCTCATGGAGAAGTTATCAGACACTCTGGCTGGTTTGGAATGC
  TTCTTCTCAGGCATGAACATGTACTGTTCTCTTCTTGAACACTCATGCTGAAAGCCCAAG
  TAGGGGGTCTAAAATTTTTAAGGACTTTCCTTCCTCCATCTCCAAGAATGCTGAAACCAA
  GGGGGATGACATGTGACTCCTATGATCTCAGGTTCTCCTTGATTGGGACTGGGGCTGAAG
  GTTGAAGAGGTGAGCACGGCCAACAAAGCTGTTGATGGTAGGTGGCACACTGGGTGCCCA
  AGCTCAGAAGGCTCTTCTGACTACTGGGCAAAGAGTGTAGATCAGAGCAGCAGTGAAAAC
  AAGTGCTGGCACCACCAGGCACCTCACAGAAATGAGATCAGGCTCTGCCTCACCTTGGGG
  CTTGACTTTTGTATAGGTAGATGTTCAGATTGCTTTGATTAATCCAGAATAACTAGCACC
  AGGGACTATGAATGGGCAAAACTGAATTATAAGAGGCTGATAATTCCAGTGGTCCATGGA
  ATGCTTGAAAAATGTGCAAAACAGCGTTTAAGACTGTAATGAATCTAAGCAGCATTTCTG
  AAGTGGACTCTTTGGTGGCTTTGCATTTTAAAAATGAAATTTTCCAATGTCTGCCACACA
  AACGTATGTAAATGTATATACCCACACACATACACACATATGTCATATATTACTAGCATA
  TGAATTTCATAGCTAAGAAATAAAACTGTTAAAGTCTCAAAAAAAAAAAAAAAAAAAAAA
  AAA
• Restriction Sites: Please inquire
• ACCN: NM_006564
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_006564.1, NP_006555.1
• RefSeq Size: 1953 bp
• RefSeq ORF: 1029 bp
• Locus ID: 10663
• UniProt ID: O00574
• Cytogenetics: 3p21.31
• Domains: 7tm_1
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]