BMP5 (NM_021073) Human Untagged Clone

CAT#: SC321699

BMP5 (untagged)-Human bone morphogenetic protein 5 (BMP5)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BMP5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_021073.2 CTCTTGAAGAGGGCTGGTATATTTGTGCCTGCTGGAGGTGGAATTAACAGTAAGAAGGAG
  AAAGGGATTGAATGGACTTACAGGAAGGATTTCAAGTAAATTCAGGGAAACACATTTACT
  TGAATAGTACAACCTAGAGTATTATTTTACACTAAGACGACACAAAAGATGTTAAAGTTA
  TCACCAAGCTGCCGGACAGATATATATTCCAACACCAAGGTGCAGATCAGCATAGATCTG
  TGATTCAGAAATCAGGATTTGTTTTGGAAAGAGCTCAAGGGTTGAGAAGAACTCAAAAGC
  AAGTGAAGATTACTTTGGGAACTACAGTTTATCAGAAGATCAACTTTTGCTAATTCAAAT
  ACCAAAGGCCTGATTATCATAAATTCATATAGGAATGCATAGGTCATCTGATCAAATAAT
  ATTAGCCGTCTTCTGCTACATCAATGCAGCAAAAACTCTTAACAACTGTGGATAATTGGA
  AATCTGAGTTTCAGCTTTCTTAGAAATAACTACTCTTGACATATTCCAAAATATTTAAAA
  TAGGACAGGAAAATCGGTGAGGATGTTGTGCTCAGAAATGTCACTGTCATGAAAAATAGG
  TAAATTTGTTTTTTCAGCTACTGGGAAACTGTACCTCCTAGAACCTTAGGTTTTTTTTTT
  TTTTAAGAGGACAAGAAGGACTAAAAATATCAACTTTTGCTTTTGGACAAAAATGCATCT
  GACTGTATTTTTACTTAAGGGTATTGTGGGTTTCCTCTGGAGCTGCTGGGTTCTAGTGGG
  TTATGCAAAAGGAGGTTTGGGAGACAATCATGTTCACTCCAGTTTTATTTATAGAAGACT
  ACGGAACCACGAAAGACGGGAAATACAAAGGGAAATTCTCTCTATCTTGGGTTTGCCTCA
  CAGACCCAGACCATTTTCACCTGGAAAACAAGCGTCCTCTGCACCTCTCTTTATGCTGGA
  TCTCTACAATGCCATGACCAATGAAGAAAATCCTGAAGAGTCGGAGTACTCAGTAAGGGC
  ATCCTTGGCAGAAGAGACCAGAGGGGCAAGAAAGGGATACCCAGCCTCTCCCAATGGGTA
  TCCTCGTCGCATACAGTTATCTCGGACGACTCCTCTGACCACCCAGAGTCCTCCTCTAGC
  CAGCCTCCATGATACCAACTTTCTGAATGATGCTGACATGGTCATGAGCTTTGTCAACTT
  AGTTGAAAGAGACAAGGATTTTTCTCACCAGCGAAGGCATTACAAAGAATTTCGATTTGA
  TCTTACCCAAATTCCTCATGGAGAGGCAGTGACAGCAGCTGAATTCCGGATATACAAGGA
  CCGGAGCAACAACCGATTTGAAAATGAAACAATTAAGATTAGCATATATCAAATCATCAA
  GGAATACACAAATAGGGATGCAGATCTGTTCTTGTTAGACACAAGAAAGGCCCAAGCTTT
  AGATGTGGGTTGGCTTGTCTTTGATATCACTGTGACCAGCAATCATTGGGTGATTAATCC
  CCAGAATAATTTGGGCTTACAGCTCTGTGCAGAAACAGGGGATGGACGCAGTATCAACGT
  AAAATCTGCTGGTCTTGTGGGAAGACAGGGACCTCAGTCAAAACAACCATTCATGGTGGC
  CTTCTTCAAGGCGAGTGAGGTACTTCTTCGATCCGTGAGAGCAGCCAACAAACGAAAAAA
  TCAAAACCGCAATAAATCCAGCTCTCATCAGGACTCCTCCAGAATGTCCAGTGTTGGAGA
  TTATAACACAAGTGAGCAAAAACAAGCCTGTAAGAAGCACGAACTCTATGTGAGCTTCCG
  GGATCTGGGATGGCAGGACTGGATTATAGCACCAGAAGGATACGCTGCATTTTATTGTGA
  TGGAGAATGTTCTTTTCCACTTAACGCCCATATGAATGCCACCAACCACGCTATAGTTCA
  GACTCTGGTTCATCTGATGTTTCCTGACCACGTACCAAAGCCTTGTTGTGCTCCAACCAA
  ATTAAATGCCATCTCTGTTCTGTACTTTGATGACAGCTCCAATGTCATTTTGAAAAAATA
  TAGAAATATGGTAGTACGCTCATGTGGCTGCCACTAATATTAAATAATATTGATAATAAC
  AAAAAGATCTGTATTAAGGTTTATGGCTGCAATAAAAAGCATACTTTCAGACAAACGGGG
  AATTTCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_021073
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021073.2, NP_066551.1
• RefSeq Size: 2207 bp
• RefSeq ORF: 1365 bp
• Locus ID: 653
• UniProt ID: P22003
• Cytogenetics: 6p12.1
• Domains: TGFb_propeptide, TGF-beta
• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
• Protein Pathways: Hedgehog signaling pathway, TGF-beta signaling pathway
• Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).