Claudin 4 (CLDN4) (NM_001305) Human Untagged Clone

CAT#: SC321565

CLDN4 (untagged)-Human claudin 4 (CLDN4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Claudin 4
• Synonyms: CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001305.3 GGCAGCTGTCGGCTGGAAGGAACTGGTCTGCTCACACTTGCTGGCTTGCGCATCAGGACT
  GGCTTTATCTCCTGACTCACGGTGCAAAGGTGCACTCTGCGAACGTTAAGTCCGTCCCCA
  GCGCTTGGAATCCTACGGCCCCCACAGCCGGATCCCCTCAGCCTTCCAGGTCCTCAACTC
  CCGCGGACGCTGAACAATGGCCTCCATGGGGCTACAGGTAATGGGCATCGCGCTGGCCGT
  CCTGGGCTGGCTGGCCGTCATGCTGTGCTGCGCGCTGCCCATGTGGCGCGTGACGGCCTT
  CATCGGCAGCAACATTGTCACCTCGCAGACCATCTGGGAGGGCCTATGGATGAACTGCGT
  GGTGCAGAGCACCGGCCAGATGCAGTGCAAGGTGTACGACTCGCTGCTGGCACTGCCGCA
  GGACCTGCAGGCGGCCCGCGCCCTCGTCATCATCAGCATCATCGTGGCTGCTCTGGGCGT
  GCTGCTGTCCGTGGTGGGGGGCAAGTGTACCAACTGCCTGGAGGATGAAAGCGCCAAGGC
  CAAGACCATGATCGTGGCGGGCGTGGTGTTCCTGTTGGCCGGCCTTATGGTGATAGTGCC
  GGTGTCCTGGACGGCCCACAACATCATCCAAGACTTCTACAATCCGCTGGTGGCCTCCGG
  GCAGAAGCGGGAGATGGGTGCCTCGCTCTACGTCGGCTGGGCCGCCTCCGGCCTGCTGCT
  CCTTGGCGGGGGGCTGCTTTGCTGCAACTGTCCACCCCGCACAGACAAGCCTTACTCCGC
  CAAGTATTCTGCTGCCCGCTCTGCTGCTGCCAGCAACTACGTGTAAGGTGCCACGGCTCC
  ACTCTGTTCCTCTCTGCTTTGTTCTTCCCTGGACTGAGCTCAGCGCAGGCTGTGACCCCA
  GGAGGGCCCTGCCACGGGCCACTGGCTGCTGGGGACTGGGGACTGGGCAGAGACTGAGCC
  AGGCAGGAAGGCAGCAGCCTTCAGCCTCTCTGGCCCACTCGGACAACTTCCCAAGGCCGC
  CTCCTGCTAGCAAGAACAGAGTCCACCCTCCTCTGGATATTGGGGAGGGACGGAAGTGAC
  AGGGTGTGGTGGTGGAGTGGGGAGCTGGCTTCTGCTGGCCAGGATGGCTTAACCCTGACT
  TTGGGATCTGCCTGCATCGGTGTTGGCCACTGTCCCCATTTACATTTTCCCCACTCTGTC
  TGCCTGCATCTCCTCTGTTGCGGGTAGGCCTTGATATCACCTCTGGGACTGTGCCTTGCT
  CACCGAAACCCGCGCCCAGGAGTATGGCTGAGGCCTTGCCCACCCACCTGCCTGGGAAGT
  GCAGAGTGGATGGACGGGTTTAGAGGGGAGGGGCGAAGGTGCTGTAAACAGGTTTGGGCA
  GTGGTGGGGGAGGGGGCCAGAGAGGCGGCTCAGGTTGCCCAGCTCTGTGGCCTCAGGACT
  CTCTGCCTCACCCGCTTCAGCCCAGGGCCCCTGGAGACTGATCCCCTCTGAGTCCTCTGC
  CCCTTCCAAGGACACTAATGAGCCTGGGAGGGTGGCAGGGAGGAGGGGACAGCTTCACCC
  TTGGAAGTCCTGGGGTTTTTCCTCTTCCTTCTTTGTGGTTTCTGTTTTGTAATTTAAGAA
  GAGCTATTCATCACTGTAATTATTATTATTTTCTACAATAAATGGGACCTGTGCACAGGA
  AAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001305
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001305.3, NP_001296.1
• RefSeq Size: 1846 bp
• RefSeq ORF: 630 bp
• Locus ID: 1364
• UniProt ID: O14493
• Cytogenetics: 7q11.23
• Domains: PMP22_Claudin
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
• Gene Summary: The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]