Retinoid X Receptor beta (RXRB) (NM_021976) Human Untagged Clone

CAT#: SC319407

RXRB (untagged)-Human retinoid X receptor, beta (RXRB)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Retinoid X Receptor beta
• Synonyms: DAUDI6; H-2RIIBP; NR2B2; RCoR-1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_021976.3 CAAAGATGGCTGCCACATTGGCGCTGTCATTTTGGTACTGAGCAGAGCGACGGGCTTAAT
  TCGACCCAATCCAGGCCAGAGTCTTTCTCTCAGGGGCTTCCTCGTGCTCAGCTAATCCTC
  CGATCAATCCTTGGGAATCCCTGGGACCTCTTCGGTATCCCTACTCTCAGCCAGGGATCA
  TGTCTTGGGCCGCTCGCCCGCCCTTCCTCCCTCAGCGGCATGCCGCAGGGCAGTGTGGGC
  CGGTGGGGGTGCGAAAAGAAATGCATTGTGGGGTCGCGTCCCGGTGGCGGCGGCGACGGC
  CCTGGCTGGATCCCGCAGCGGCGGCGGCGGCGGCGGTGGCAGGCGGAGAACAACAAACCC
  CGGAGCCGGAGCCAGGGGAGGCTGGACGGGACGGGATGGGCGACAGCGGGCGGGACTCCC
  GAAGCCCAGACAGCTCCTCCCCAAATCCCCTTCCCCAGGGAGTCCCTCCCCCTTCTCCTC
  CTGGGCCACCCCTACCCCCTTCAACAGCTCCATCCCTTGGAGGCTCTGGGGCCCCACCCC
  CACCCCCGATGCCACCACCCCCACTGGGCTCTCCCTTTCCAGTCATCAGTTCTTCCATGG
  GGTCCCCTGGTCTGCCCCCTCCAGCTCCCCCAGGATTCTCCGGGCCTGTCAGCAGCCCCC
  AGATTAACTCAACAGTGTCACTCCCTGGGGGTGGGTCTGGCCCCCCTGAAGATGTGAAGC
  CACCAGTCTTAGGGGTCCGGGGCCTGCACTGTCCACCCCCTCCAGGTGGCCCTGGGGCTG
  GCAAACGGCTATGTGCAATCTGCGGGGACAGAAGCTCAGGCAAACACTACGGGGTTTACA
  GCTGTGAGGGTTGCAAGGGCTTCTTCAAACGCACCATCCGCAAAGACCTTACATACTCTT
  GCCGGGACAACAAAGACTGCACAGTGGACAAGCGCCAGCGGAACCGCTGTCAGTACTGCC
  GCTATCAGAAGTGCCTGGCCACTGGCATGAAGAGGGAGGCGGTACAGGAGGAGCGTCAGC
  GGGGAAAGGACAAGGATGGGGATGGGGAGGGGGCTGGGGGAGCCCCCGAGGAGATGCCTG
  TGGACAGGATCCTGGAGGCAGAGCTTGCTGTGGAACAGAAGAGTGACCAGGGCGTTGAGG
  GTCCTGGGGGAACCGGGGGTAGCGGCAGCAGCCCAAATGACCCTGTGACTAACATCTGTC
  AGGCAGCTGACAAACAGCTATTCACGCTTGTTGAGTGGGCGAAGAGGATCCCACACTTTT
  CCTCCTTGCCTCTGGATGATCAGGTCATATTGCTGCGGGCAGGCTGGAATGAACTCCTCA
  TTGCCTCCTTTTCACACCGATCCATTGATGTTCGAGATGGCATCCTCCTTGCCACAGGTC
  TTCACGTGCACCGCAACTCAGCCCATTCAGCAGGAGTAGGAGCCATCTTTGATCGGGTGC
  TGACAGAGCTAGTGTCCAAAATGCGTGACATGAGGATGGACAAGACAGAGCTTGGCTGCC
  TGAGGGCAATCATTCTGTTTAATCCAGATGCCAAGGGCCTCTCCAACCCTAGTGAGGTGG
  AGGTCCTGCGGGAGAAAGTGTATGCATCACTGGAGACCTACTGCAAACAGAAGTACCCTG
  AGCAGCAGGGACGGTTTGCCAAGCTGCTGCTACGTCTTCCTGCCCTCCGGTCCATTGGCC
  TTAAGTGTCTAGAGCATCTGTTTTTCTTCAAGCTCATTGGTGACACCCCCATCGACACCT
  TCCTCATGGAGATGCTTGAGGCTCCCCATCAACTGGCCTGAGCTCAGACCCAGACGTGGT
  GCTTCTCACACTGGAGGAGCACACATCCAAGAGGGACTCCAAGCCCTGGGGCAGGGTGGG
  GGGCCATGTTCCCAGAACCTTGATGGGGTGAGAAGTACAGGGCAGAACCAAGAACATAAA
  CCCTCCAAGGGATCTGCTTGATATCCCAAGTTGGAAGGGACCCCAGATACCTGTGAGGAC
  TGGTTGTCTCTCTTCGGTGGCCTTGAGTCTCTGAATTTGTCGGGGTCTCCCATGATTTGG
  GGTGATTTCTCACCCTCTGTCCTTCCCCCAGCACAAAGCACTGGCCTTGCCTCCAGGACC
  TTGCTTCCTTCTCATCTTGCCTCATTTTGCTTCCCATCTGAAGAGTGGAAATGGGGAACT
  CCCCCAGAGGTGGATACTGGGGGGCAGGCCTCCCAAGCTGATGGACATGAGAGTAGGGCC
  CTGACAGGCCTTCCTCCTCTCAAACCTGGCAGATGGGGGCCTCTCTGGAAGAGGGAGGGG
  CCCTGTCACTGTCCAGAGTCTCTTTTTACACTTCACCTCCTTCTGCAGTCAGACTGAAAT
  ATAAAAAAGGTGGTGGTGGTGGTGAAGGGGCTGGTGGAGATGTAGGAACCGATCTGCTAT
  TTTTAATTTCCTGTGAGGATAGAGACTTGCAGTTAGACTCAAAGAAGTACTGTACTTTCC
  CAGGTTGACTAAGAAATGCCAGTGGTGGAGGTGGGTGTTTGGGAAAGGCAGGGCCCTGAA
  ATGGCCTGTCCCTAGGGCTCTCCAAGCACTAGCCTTCCCAGCTTCCCGCCGCCCCCCCCA
  TCTCTTCCTGTCTAACTTGGGGAAGGGGCCTGGGCTGTGAGGACAGGGCCCCCACAGGGG
  ATGGTTTCACGAGTGTAGTCCCGGAGGCCTTCCCTTTACAGCTCTCCTCCAGCCCTGGGC
  ACATAGCATAGGCTGGGGACACAGGATCCTGGCCTGAGAATTGAGGGGAGGTGGCCAGCC
  CGCAGAGGTGGGGTGCTGGGGCTGCATGATTTTTGCCCTGCGTCCCTTCTCTTTGGGGCT
  CCTTTCCCCTCTCATACATAAAATCGCTTTCAAATTAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_021976
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021976.3, NP_068811.1
• RefSeq Size: 2892 bp
• RefSeq ORF: 1602 bp
• Locus ID: 6257
• UniProt ID: P28702
• Cytogenetics: 6p21.32
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer
• Gene Summary: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.