Tau tubulin kinase 2 (TTBK2) (NM_173500) Human Untagged Clone

CAT#: SC309233

TTBK2 (untagged)-Human tau tubulin kinase 2 (TTBK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Tau tubulin kinase 2
• Synonyms: SCA11; TTBK
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_173500 edited
  CCGCCGCCAGTAAACGCGGACCGTACCCCAGGGGACTACCCAGCCGGCCGGCCCTGGAAG
  CCGCGCTCGGGTCCCGCCGCAGTCGGCGGTGGGGGATGGGCAGGCAGTGGCGGTCCCGCC
  TGCCGAGGGTTAACCCCCGCCGGTCCCGGTCCTGAGCTGGACCAGAGCCCTCCTCCAGAA
  ACCCCTGCGTCCGCCACGGCCCAGGTTAAATGGAAACCACCCTTGGGAACTGGATGCCTG
  TGTAGCTGTTCTACCATATCAGTGTATTGCAATGAGTGGGGGAGGAGAGCAGCTGGATAT
  CCTGAGTGTTGGAATCCTAGTGAAAGAAAGATGGAAAGTGTTGAGAAAGATTGGGGGTGG
  GGGCTTTGGAGAAATTTACGATGCCTTGGACATGCTCACCAGGGAAAATGTTGCACTGAA
  GGTGGAATCAGCTCAACAACCAAAACAAGTTCTGAAAATGGAAGTTGCTGTTTTGAAAAA
  GCTGCAAGGGAAAGACCATGTTTGTAGATTTATTGGCTGTGGGAGGAATGATCGATTCAA
  CTATGTGGTCATGCAGTTGCAGGGTCGGAATCTGGCAGATCTTCGCCGTAGCCAGTCCCG
  AGGCACATTCACCATTAGTACCACTCTCCGGCTGGGTAGACAGATTTTGGAGTCTATTGA
  AAGCATTCATTCTGTGGGATTCTTGCATCGAGACATCAAACCGTCGAACTTCGCTATGGG
  TCGCTTTCCTAGTACATGTAGGAAATGTTACATGCTTGATTTTGGCTTGGCTCGACAATT
  TACCAATTCCTGTGGTGACGTCAGACCACCTCGAGCTGTGGCAGGTTTTCGAGGGACAGT
  TCGTTATGCATCAATCAACGCACATCGGAACAGGGAAATGGGAAGACATGATGACCTTTG
  GTCCTTATTCTACATGTTGGTGGAGTTTGTGGTTGGTCAGCTGCCCTGGAGAAAAATAAA
  GGACAAGGAGCAAGTAGGCTCTATTAAGGAGAGATATGACCACAGGCTCATGTTGAAACA
  TCTCCCTCCAGAATTCAGCATCTTTCTAGACCATATCTCTTCTTTGGATTATTTTACAAA
  ACCAGACTACCAGCTTCTTACATCCGTGTTTGACAATAGCATCAAGACTTTTGGAGTAAT
  TGAGAGTGACCCTTTTGACTGGGAGAAGACTGGAAATGATGGCTCCCTAACAACCACCAC
  TACTTCTACCACCCCTCAGTTGCACACTCGCTTGACCCCTGCTGCAATTGGAATTGCCAA
  TGCTACTCCCATCCCTGGAGACTTGCTTCGAGAAAATACAGATGAGGTATTTCCAGATGA
  ACAGCTTAGCGATGGAGAAAATGGCATCCCTGTTGGTGTGTCACCAGATAAATTGCCTGG
  ATCTCTGGGACACCCCCGTCCCCAGGAGAAGGATGTTTGGGAAGAGATGGATGCCAACAA
  AAACAAGATAAAGCTTGGAATTTGTAAGGCTGCTACTGAAGAGGAGAACAGCCATGGCCA
  GGCAAATGGTCTTCTCAATGCTCCAAGCCTTGGGTCACCAATTCGTGTCCGCTCAGAGAT
  TACTCAGCCAGACAGAGATATTCCACTGGTGCGAAAGTTACGTTCCATTCACAGCTTTGA
  GCTGGAAAAACGTCTGACCCTGGAGCCAAAGCCAGACACTGACAAGTTCCTTGAGACCTG
  CCTGGAGAAAATGCAGAAAGATACCAGTGCAGGAAAAGAATCTATTCTCCCTGCTCTGCT
  GCATAAGCCTTGCGTTCCTGCTGTGTCCCGTACTGACCACATCTGGCACTATGATGAAGA
  ATATCTTCCAGATGCCTCCAAGCCTGCTTCTGCCAACACCCCTGAGCAGGCAGATGGTGG
  TGGCAGCAATGGATTTATAGCTGTTAACCTGAGCTCTTGCAAGCAAGAAATTGATTCCAA
  AGAATGGGTGATTGTGGACAAGGAGCAGGACCTTCAGGATTTTAGGACAAATGAGGCTGT
  AGGACATAAAACAACTGGAAGTCCTTCTGATGAGGAGCCTGAAGTACTTCAAGTCCTGGA
  GGCATCACCTCAAGATGAAAAGCTCCAGTTAGGTCCTTGGGCAGAAAATGATCATTTAAA
  GAAGGAAACCTCAGGTGTGGTCTTAGCACTTTCTGCAGAGGGTCCTCCTACTGCTGCTTC
  AGAACAATATACAGATAGGCTGGAACTCCAGCCTGGAGCTGCTAGTCAGTTTATTGCAGC
  GACGCCCACAAGTCTAATGGAGGCGCAGGCAGAAGGACCCCTTACAGCGATTACAATTCC
  TAGACCTTCTGTGGCATCTACACAGTCAACTTCAGGAAGCTTTCACTGTGGTCAGCAGCC
  AGAGAAGAAAGATCTTCAGCCCATGGAGCCCACTGTGGAACTTTACTCTCCAAGGGAAAA
  CTTCTCTGGCTTGGTTGTGACAGAGGGTGAACCTCCTAGTGGAGGAAGCAGAACAGATTT
  GGGGCTTCAGATAGATCACATTGGTCATGACATGTTACCCAACATTAGAGAAAGTAACAA
  ATCTCAAGACCTGGGACCAAAAGAACTTCCTGATCATAATAGACTGGTTGTGAGAGAATT
  TGAAAATCTCCCTGGGGAAACTGAAGAGAAAAGCATCCTTTTAGAGTCAGATAATGAAGA
  TGAGAAGTTAAGTAGAGGGCAGCATTGTATTGAGATCTCCTCTCTCCCAGGAGATTTGGT
  AATTGTGGAAAAGGATCACTCAGCTACTACTGAACCTCTTGATGTGACAAAAACACAGAC
  TTTTAGTGTGGTGCCAAATCAAGACAAAAATAATGAGATAATGAAGCTTCTGACAGTTGG
  AACTTCAGAAATTTCTTCCAGAGACATTGACCCACATGTTGAAGGTCAGATAGGCCAAGT
  GGCAGAAATGCAAAAAAATAAGATATCTAAGGATGATGACATCATGAGTGAAGACTTGCC
  AGGTCATCAAGGAGACCTCTCTACTTTTTTGCACCAAGAGGGCAAGAGAGAGAAAATCAC
  CCCTAGAAATGGAGAACTATTTCATTGTGTTTCAGAGAATGAACATGGTGCCCCAACCCG
  GAAGGATATGGTTAGGTCATCCTTTGTAACTAGACACAGCCGAATCCCTGTTTTAGCACA
  AGAGATAGACTCAACTTTGGAATCATCCTCTCCAGTTTCTGCAAAAGAAAAGCTCCTCCA
  AAAGAAAGCCTATCAGCCAGACCTAGTCAAGCTTCTGGTGGAAAAAAGACAATTCAAGTC
  CTTCCTTGGCGACCTCTCAAGTGCCTCTGATAAATTGCTAGAGGAGAAACTAGCTACTGT
  TCCTGCTCCCTTTTGTGAGGAGGAAGTGCTCACTCCCTTTTCAAGACTGACAGTAGATTC
  TCACCTGAGTAGGTCAGCTGAAGATAGCTTTCTGTCACCCATCATCTCCCAGTCTAGAAA
  GAGCAAAATTCCAAGGCCAGTTTCATGGGTCAACACAGATCAGGTCAATAGCTCAACTTC
  GTCTCAGTTCTTTCCTCGGCCACCACCAGGAAAGCCACCCACGAGGCCTGGAGTAGAAGC
  CAGGCTACGCAGATATAAAGTCCTAGGGAGTAGTAACTCCGACTCAGACCTTTTCTCCCG
  CCTGGCCCAAATTCTTCAAAATGGATCTCAGAAACCCCGGAGCACTACTCAGTGCAAGAG
  TCCAGGATCTCCTCACAATCCAAAAACACCACCCAAGAGTCCAGTTGTCCCTCGCAGGAG
  TCCCAGTGCCTCTCCTCGAAGCTCATCCTTGCCTCGCACGTCTAGTTCCTCACCATCTAG
  GGCTGGACGGCCCCACCATGACCAGAGGAGTTCGTCCCCACATCTGGGGAGAAGCAAGTC
  ACCTCCCAGCCACTCAGGATCTTCCTCCTCCAGGAGGTCCTGCCAACAGGAGCATTGCAA
  ACCCAGCAAGAATGGCCTGAAAGGATCCGGCAGCCTCCACCACCACTCAGCCAGCACTAA
  AACCCCCCAAGGGAAGAGTAAGCCAGCCAGTAAACTCAGCAGATAGGAGCCAGGCTGCAT
  CTCTTTGAAAGGTGTGAGATCTTCCTCCTAAACCTGATGCATGTGTGTCCCTGTACTTTC
  TATGTAAAAAAATCAGTGTTGATCTTCTCTTGCAAAAGAAAGTAACATGATCAATTATTT
  ATAAGAAGACATAATACATGATAAGGAATTACCTAAGGCAGGCAGCAAGTAGATTAGGAA
  TCAATGTCXXXXXXXXXXXXXXXXXATTTTATACATTTAGCCAATAAGGAATTAATATCT
  GGGGAAATAAATTTAGGCAAATATTTCTTTTTTAATGTTTTATTACCTGCTTCTCCTGTG
  TTTTAGTTCAACATTTGGGCTTNTTGGCCTGATTTTCATACAATCTCAATTTACGAAGCT
  GTAAAGAGGAAGATATTTGTTCTAATCTCACTCTTCTAATAGGAATCAGCCAAATGAAAG
  TCTACCAGACTTTTAAAATGGGGCTGTTTTTATACTCTCTAGGTGTTTTGTGTTGTAAAG
  ACCTTATTAAGGTCAGGTAAATTGGTCTGCTTGCTGTTGAAATTTGCCTTCTAGCAAACA
  TATGTGCTTTCTGTTTGACCTTGTGTTTGCTGCCAAACCTAATACAGTTGAATTGGGAAA
  CAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_173500 unedited
  CTTATACCCCCGCCCGTTGNCGCAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATA
  AGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCC
  GCGAATTCGGCACGAGGGTCAGCGGGCTCTGCAGTAGTCGCCGCAGCGGCGATGGGAGCG
  GTGGGGACGAGGCGGCNNCNNCNGCANGAGGGGGAGCAGGTGCTGGCACAAGAGCAGCGG
  CTTGGGGGAGCCGGCAGCAGCAGTAACAGCAGCAGCAGCCGCCGCCGCCGCCGCCAGTAA
  ACGCGGACCGTACCCCAGGGGACTACCCAGCCGGCCGGCCCTGGAAGCCGCGCTCGGGTC
  CCGCCGCAGTCGGCGGTGGGGGATGGGCAGGCAGTGGCGGTCCCGCCTGCCGAGGGTTAA
  CCCCCGCCGGTCCCGGTCCTGAGCTGGACCAGAGCCCTTCTCCAGAAACCCCTGCGTTCG
  CCACGGCCCACGTTAAATGGAAACCCCCCTTGGGCACCGCCAGCCTGTGCATCTGTTCTA
  CCATATCATCGCATTGCAATGAGTGCCGGACGACAGCCGCCTGATATCCCGCGTGGTGGG
  ATCCTTATTAAAGAAACCAGGAAAGTCCCCACCCAGAATTTGGGCCGCCGGCTTCTGACC
  ACATAATCCTCCTCTTCCCTCTTCTCATGCCCAATCCGCTCTCCCCGGGGATATACTCCC
  CCTCCACCATCCTTTTTCAAAAGGCACTCTCCGTTCCAAAAAACTTCCCCGGTAAAACTC
  CCTCCCCTACATCAATGCGTCGGCGCGGCAATCCTTTCTTACCCTTCCCTCCTTCTTCCC
  CTTCCCGCATCCTCTTAACCTTCGTGTTCTCCCGCCTCGGCCTTATCACCCTACATCCCC
  ACCCGCCGCGGTAACGAACCTGCGCTCCCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_173500 unedited
  GGATTACATGNACGCGGCCGCTTTCTANGATCGAGTTTTTTTTTTTTTTTTTTGTTTCCC
  AATTCAACTGTATTAGGTTTGGCAGCAAACACAAGGTCAAACAGAAAGCACATATGTTTG
  CTAGAAGGCAAATTTCAACAGCAAGCAGACCAATTTACCTGACCTTAATAAGGTCTTTAC
  AACACAAAACACCTAGAGAGTATAAAAACAGCCCATTTTAAAAGTCTGGTAGACTTTCAT
  TTGCCTGATTCCTATTAGAAGAGTGAGATTAGAACAAATATCTTCCTCTTTACAGCTTCG
  TAAATTGAGATTGTATGAAAATCAGGCCAAGAAGCCCAAATGTTGAACTAAAACACAGGA
  GAAGCAGGTAATAAAACATTAAAAAAGAAATATTTGCCTAAATTTATTTCCCCAGATATT
  AATTCCTTATTGGCTAAATGTATAAAATACAAAGTTTGAGGATTCTAAGCCTCAATAATA
  TATCTAATTTATTTCTAAATCTCAAATCACAGTCCAAAGCATTGGGCTTCCCTCGTATCA
  TCTTGGATGCTGATATTACCAACAGTTGGGACCCCGAAGACTTAAGGAAGCAGCCTACTC
  TGGGCAGTTTTTCCTCTACCTCAATTTTTAAAGGGAGGACCCTTAACAAAGATTGAAAGG
  GGATCTTTCTATTCTTGAAGGCGTTTTAACCCCCACCTTTTTTTTTTTTCCTAAAAACTA
  AAAGCCTGGAAAAAAAGCCCCTAGGTAGAACTTTTTTTTTCCTTTCCCTCACCTTTCCTA
  ATTTTTTACATAATAAAAAAGGGAAATATGGTTTAAAAAATTCTGGCTCTAAAAAAAAAA
  AAATACGAGGGGACACTAAAAAAAAAATAATTGGCGTTTTTGAGGCCCACCCCGGGGCCC
  TATAAATAAAAGCCGAGAAGTTTGGGT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_173500
• Insert Size: 6000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_173500.2, NP_775771.2
• RefSeq Size: 5613 bp
• RefSeq ORF: 4950 bp
• Locus ID: 146057
• UniProt ID: Q6IQ55
• Cytogenetics: 15q15.2
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]