Langerin (CD207) (NM_015717) Human Untagged Clone

CAT#: SC304348

CD207 (untagged)-Human CD207 molecule, langerin (CD207)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Langerin
• Synonyms: CLEC4K
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_015717 edited
  AGAAGCACCTGTGCTCCCAGGATAAGGGTGAGCACTCAGGATGACTGTGGAGAAGGAGGC
  CCCTGATGCGCACTTCACTGTGGACAAACAGAACATCTCCCTCTGGCCCCGAGAGCCTCC
  TCCCAAGTCCGGTCCATCTCTGGTCCCGGGGAAAACACCCACAGTCCGTGCTGCATTAAT
  CTGCCTGACGCTGGTCCTGGTCGCCTCCGTCCTGCTGCAGGCCGTCCTTTATCCCCGGTT
  TATGGGCACCATATCAGATGTAAAGACCAATGTCCAGTTGCTGAAAGGTCGTGTGGACAA
  CATCAGCACCCTGGATTCTGAAATTAAAAAGAATAGTGACGGCATGGAGGCAGCTGGCGT
  TCAGATCCAGATGGTGAATGAGAGCCTGGGTTATGTGCGTTCTCAGTTCCTGAAGTTAAA
  AACCAGTGTGGAGAAGGCCAACGCACAGATCCAGATCTTAACAAGAAGTTGGGAAGAAGT
  CAGTACCTTAAATGCCCAAATCCCAGAGTTAAAAAGTGATTTGGAGAAAGCCAGTGCTTT
  AAATACAAAGATCCGGGCACTCCAGGGCAGCTTGGAGAATATGAGCAAGTTGCTCAAACG
  ACAAAATGATATTCTACAGGTGGTTTCTCAAGGCTGGAAGTACTTCAAGGGGAACTTCTA
  TTACTTTTCTCTCATTCCAAAGACCTGGTATAGTGCCGAGCAGTTCTGTGTGTCCAGGAA
  TTCACACCTGACCTCGGTGACCTCAGAGAGTGAGCAGGAGTTTCTGTATAAAACAGCGGG
  GGGACTCATCTACTGGATTGGCCTGACTAAAGCAGGGATGGAAGGGGACTGGTCCTGGGT
  GGATGACACGCCATTCAACAAGGTCCAAAGTGCGAGGTTCTGGATTCCAGGTGAGCCCAA
  CAATGCTGGGAACAATGAACACTGTGGCAATATAAAGGCTCCCTCACTTCAGGCCTGGAA
  TGATGCCCCATGTGACAAAACGTTTCTTTTCATTTGTAAGCGACCCTATGTCCCATCAGA
  ACCGTGACAGGACAGGCTCCCAAGCTCACTCTTTGAGCTCCAACGCTTGTTAAACATGAG
  GAAATGCCTCTTTCTTCCCCAGACTCCAGGATGACTTTGCACGTTAATTTTTCTTGCTTC
  AAAATTGTCCCACAGTGGCATTCTGGAGTCCGTCTGTCTTGGCTGGAAATTCTCTGACGT
  CTTGGAGGCAGCTGGAATGGAAAGGAGAATTCAGGTTAAAGTGGGAGGGGTGGGTAGAGA
  GGATTTAGAAGTTCCAATTGCCCTGCTAAGGAGGATCAAGACCCGTAATCCGGCACAACA
  CCCTGGGGTTTTCCACTCTTTCAGAGAAACCTCAGCTTCATCACATCAAAGTTACTCCAG
  AGCAACCAAGCAATTCTCCTGATATTGTCATCCAGGGCTTTTCTTGGCCAAACCCCCTAG
  AATTTCCATGTCTCTGCTTAGCTGTGCTGGCAGCTAGCAGCTGGCTGTGTTTGCAGTGCA
  AATAGCTCTGTTCTTGGAAATCCTGCTCATGGTATGTCCCCAGTGGTTTCTTCATCCACA
  TCATCTAAAGCCTGAACCCGTTCTTCTCTGGTTCAAGTCAGTGGCTGACACGGACTTGTA
  TCTCCTTCAGAGCTCGGCTGGCACCCAGCCTCCCTTCTCCTTCCACTCCCTTAGTACACT
  GGAGTGCCGAGCCCTGCCTTCCACCCAGCGTCCATCCAGCCCCTGTCCTCACCTCTCCGG
  CACCTCCTCCTCCTTCTGCATTTCCTATCTTCCTGTGTCTTGTGCATGGGAAGCAGCCTT
  CAGTGCCTTCATGAATTCACCTTCCAGCTTCCTCAGAATAAAATGCTGCCTGGGTCAAGG
  ACTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015717 unedited
  NGTGCAGGTCGTTTTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCCATTACGGCC
  GGGAGAAACACCTGTGCTCCCAGGATAAGGGTGAGCACTCAGGATGACTGTGGAGAAGGA
  GGCCCCTGATGCGCACTTCACTGTGGACAAACAGAACATCTCCCTCTGGCCCCGAGAGCC
  TCCTCCCAAGTCCGGTCCATCTCTGGTCCCGGGGAAAACACCCACAGTCCGTGCTGCATT
  AATCTGCCTGACGCTGGTCCTGGTCGCCTCCGTCCTGCTGCAGGCCGTCCTTTATCCCCG
  GTTTATGGGCACCATATCAGATGTAAAGACCAATGTCCAGTTGCTGAAAGGTCGTGTGGA
  CAACATCAGCACCCTGGATTCTGAAATTAAAAAGAATAGTGACGGCATGGAGGCAGCTGG
  CGTTCAGATCCAGATGGTGAATGAGAGCCTGGGTTATGTGCGTTCTCAGTTCCTGAAGTT
  AAAAACCAGTGTGGAGAAGGCCAACGCACAGATCCAGATCTTAACAAGAAGTTGGGAAGA
  AGTCAGTACCTTAAATGCCCAAATCCCAGAGTTAAAAAGTGATTTGGAGAAAGCCAGTGC
  TTTAAATACAAAGATCCGGGCACTCCAGGGCAGCTTGGAGAATATGAGCAAGTTGCTCAA
  ACGACAAAATGATATTCTACAGGTGGTTTCTCAAGGCTGGAAGTACTTCAAGGGGAACTT
  CTATTACTTTTCTCTCATTCCAAAGACCTGGTATAGTGCCGAGCAGTTCTGTGTGTCCAG
  GAATTCACACCTGACCTCGGTGACCTCAGAGAGTGAGCAGGAGTTTCTGTATAAAACAGC
  GGGGGGACTCATCTACTGNNATGCCCTGACTAAAGCAGG
  
• Restriction Sites: Please inquire
• ACCN: NM_015717
• Insert Size: 1900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_015717.1, NP_056532.1
• RefSeq Size: 1999 bp
• RefSeq ORF: 987 bp
• Locus ID: 50489
• UniProt ID: Q9UJ71
• Cytogenetics: 2p13.3
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]