TRPM2 (NM_003307) Human Untagged Clone

CAT#: SC303292

TRPM2 (untagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRPM2
• Synonyms: EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003307 edited
  TGTAGCGAGCTGGAGAGAGGACTGTCCTGAGGGCAGCAGGCCTGGTTGCAGCTGGCGTGG
  GGGTCTCAGAATGGAGCCCTCAGCCCTGAGGAAAGCTGGCTCGGAGCAGGAGGAGGGCTT
  TGAGGGACTGCCCAGAAGGGTCACTGACCTGGGGATGGTCTCCAATCTCCGGCGCAGCAA
  CAGCAGCCTCTTCAAGAGCTGGAGGCTACAGTGCCCCTTCGGCAACAATGACAAGCAAGA
  AAGCCTCAGTTCGTGGATTCCTGAAAACATCAAGAAGAAAGAATGCGTGTATTTTGTGGA
  AAGTTCCAAACTGTCTGATGCTGGGAAGGTGGTGTGTCAGTGTGGCTACACGCATGAGCA
  GCACTTGGAGGAGGCTACCAAGCCCCACACCTTCCAGGGCACACAGTGGGACCCAAAGAA
  ACATGTCCAGGAGATGCCAACCGATGCCTTTGGCGACATCGTCTTCACGGGCCTGAGCCA
  GAAGGTGAAAAAGTACGTCCGAGTCTCCCAGGACACGCCCTCCAGCGTGATCTACCACCT
  CATGACCCAGCACTGGGGGCTGGACGTCCCCAATCTCTTGATCTCGGTGACCGGGGGGGC
  CAAGAACTTCAACATGAAGCCGCGGCTGAAGAGCATTTTCCGCAGAGGCCTGGTCAAGGT
  GGCTCAGACCACAGGGGCCTGGATCATCACAGGGGGGTCCCACACCGGCGTCATGAAGCA
  GGTAGGCGAGGCGGTGCGGGACTTCAGCCTGAGCAGCAGCTACAAGGAAGGCGAGCTCAT
  CACCATCGGAGTCGCCACCTGGGGCACTGTCCACCGCCGCGAGGGCCTGATCCATCCCAC
  GGGCAGCTTCCCCGCCGAGTACATACTGGATGAGGATGGCCAAGGGAACCTGACCTGCCT
  AGACAGCAACCACTCTCACTTCATCCTCGTGGACGACGGGACCCACGGCCAGTACGGGGT
  GGAGATTCCTCTGAGGACCAGGCTGGAGAAGTTCATATCGGAGCAGACCAAGGAAAGAGG
  AGGTGTGGCCATCAAGATCCCCATCGTGTGCGTGGTGCTGGAGGGCGGCCCGGGCACGTT
  GTACACCATCGACAACGCCACCACCAACGGCACCCCCTGTGTGGTTGTGGAGGGCTCGGG
  CCGCGTGGCCGACGTCATTGCCCAGGTGGCCAACCTGCCTGTCTCGGACATCACTATCTC
  CCTGATCCAGCAGAAACTGAGCGTGTTCTTCCAGGAGATGTTTGAGACCTTCACGGAAAG
  CAGGATTGTCGAGTGGACCAAAAAGATCCAAGATATCGTCCGGAGGCGGCAGCTGCTGAC
  TGTCTTCCGGGAAGGCAAGGATGGTCAGCAGGACGTGGATGTGGCCATCTTGCAGGCCTT
  GCTGAAAGCCTCACGGAGCCAAGACCACTTTGGCCACGAGAACTGGGACCACCAGCTGAA
  ACTGGCAGTGGCATGGAATCGCGTGGACATTGCCCGCAGTGAGATCTTCATGGATGAGTG
  GCAGTGGAAGCCTTCAGATCTGCACCCCACGATGACAGCTGCACTCATCTCCAACAAGCC
  TGAGTTTGTGAAGCTCTTCCTGGAGAACGGGGTGCAGCTGAAGGAGTTTGTCACCTGGGA
  CACCTTGCTCTACCTGTACGAGAACCTGGACCCCTCCTGCCTGTTCCACAGCAAGCTGCA
  GAAGGTGCTGGTGGAGGATCCCGAGCGCCCGGCTTGCGCGCCCGCGGCGCCCCGCCTGCA
  GATGCACCACGTGGCCCAGGTGCTGCGGGAGCTGCTGGGGGACTTCACGCAGCCGCTTTA
  TCCCCGGCCCCGGCACAACGACCGGCTGCGGCTCCTGCTGCCCGTTCCCCACGTCAAGCT
  CAACGTGCAGGGAGTGAGCCTCCGGTCCCTCTACAAGCGTTCCTCAGGCCATGTGACCTT
  CACCATGGACCCCATCCGTGACCTTCTCATTTGGGCCATTGTCCAGAACCGTCGGGAGCT
  GGCAGGAATCATCTGGGCTCAGAGCCAGGACTGCATCGCAGCGGCCTTGGCCTGCAGCAA
  GATCCTGAAGGAACTGTCCAAGGAGGAGGAGGACACGGACAGCTCGGAGGAGATGCTGGC
  GCTGGCGGAGGAGTATGAGCACAGAGCCATCGGGGTCTTCACCGAGTGCTACCGGAAGGA
  CGAAGAGAGAGCCCAGAAACTGCTCACCCGCGTGTCCGAGGCCTGGGGGAAGACCACCTG
  CCTGCAGCTCGCCCTGGAGGCCAAGGACATGAAGTTTGTGTCTCACGGGGGCATCCAGGC
  CTTCCTGACCAAGGTGTGGTGGGGCCAGCTCTCCGTGGACAATGGGCTGTGGCGTGTGAC
  CCTGTGCATGCTGGCCTTCCCGCTGCTCCTCACCGGCCTCATCTCCTTCAGGGAGAAGAG
  GCTGCAGGATGTGGGCACCCCCGCGGCCCGCGCCCGTGCCTTCTTCACCGCACCCGTGGT
  GGTCTTCCACCTGAACATCCTCTCCTACTTCGCCTTCCTCTGCCTGTTCGCCTACGTGCT
  CATGGTGGACTTCCAGCCTGTGCCCTCCTGGTGCGAGTGTGCCATCTACCTCTGGCTCTT
  CTCCTTGGTGTGCGAGGAGATGCGGCAGCTCTTCTATGACCCTGACGAGTGCGGGCTGAT
  GAAGAAGGCAGCCTTGTACTTCAGTGACTTCTGGAATAAGCTGGACGTCGGCGCAATCTT
  GCTCTTCGTGGCAGGGCTGACCTGCAGGCTCATCCCGGCGACGCTGTACCCCGGGCGCGT
  CATCCTCTCTCTGGACTTCATCCTGTTCTGCCTCCGGCTCATGCACATTTTTACCATCAG
  TAAGACGCTGGGGCCCAAGATCATCATTGTGAAGCGGATGATGAAGGACGTCTTCTTCTT
  CCTCTTCCTGCTGGCTGTGTGGGTGGTGTCCTTCGGGGTGGCCAAGCAGGCCATCCTCAT
  CCACAACGAGCGCCGGGTGGACTGGCTGTTCCGAGGGGCCGTCTACCACTCCTACCTCAC
  CATCTTCGGGCAGATCCCGGGCTACATCGACGGTGTGAACTTCAACCCGGAGCACTGCAG
  CCCCAATGGCACCGACCCCTACAAGCCTAAGTGCCCCGAGAGCGACGCGACGCAGCAGAG
  GCCGGCCTTCCCTGAGTGGCTGACGGTCCTCCTACTCTGCCTCTACCTGCTCTTCACCAA
  CATCCTGCTGCTCAACCTCCTCATCGCCATGTTCAACTACACCTTCCAGCAGGTGCAGGA
  GCACACGGACCAGATTTGGAAGTTCCAGCGCCATGACCTGATCGAGGAGTACCACGGCCG
  CCCCGCCGCGCCGCCCCCCTTCATCCTCCTCAGCCACCTGCAGCTCTTCATCAAGAGGGT
  GGTCCTGAAGACTCCGGCCAAGAGGCACAAGCAGCTCAAGAACAAGCTGGAGAAGAACGA
  GGAGGCGGCCCTGCTATCCTGGGAGATCTACCTGAAGGAGAACTACCTCCAGAACCGACA
  GTTCCAGCAAAAGCAGCGGCCCGAGCAGAAGATCGAGGACATCAGCAATAAGGTTGACGC
  CATGGTGGACCTGCTGGACCTGGACCCACTGAAGAGGTCGGGCTCCATGGAGCAGAGGTT
  GGCCTCCCTGGAGGAGCAGGTGGCCCAGACAGCCCGAGCCCTGCACTGGATCGTGAGGAC
  GCTGCGGGCCAGCGGCTTCAGCTCGGAGGCGGACGTCCCCACTCTGGCCTCCCAGAAGGC
  CGCGGAGGAGCCGG:ATGCTGAGCCGGGAGGCAGGAAGAAGACGGAGGAGCCGGGCGACA
  GCTACCACGTGAATGCCCGGCACCTCCTCTACCCCAACTGCCCTGTCACGCGCTTCCCCG
  TGCCCAACGAGAAGGTGCCCTGGGAGACGGAGTTCCTGATCTATGACCCACCCTTTTACA
  CGGCAGAGAGGAAGGACGCGGCCGCCATGGACCCCATGGGAGACACCCTGGAGCCACTGT
  CCACGATCCAGTACAACGTGGTGGATGGCCTGAGGGACCGCCGGAGCTTCCACGGGCCGT
  ACACAGTGCAGGCCGGGTTGCCCCTGAACCCCATGGGCCGCACAGGACTGCGTGGGCGCG
  GGAGCCTCAGCTGCTTCGGACCCAACCACACGCTGTACCCCATGGTCACGCGGTGGAGGC
  GGAACGAGGATGGAGCCATCTGCAGGAAGAGCATAAAGAAGATGCTGGAAGTGCTGGTGG
  TGAAGCTCCCTCTCTCCGAGCACTGGGCCCTGCCTGGGGGCTCCCGGGAGCCAGGGGAGA
  TGCTACCTCGGAAGCTGAAGCGGATCCTCCGGCAGGAGCACTGGCCGTCTTTTGAAAACT
  TGCTGAAGTGCGGCATGGAGGTGTACAAAGGCTACATGGATGACCCGAGGAACACGGACA
  ATGCCTGGATCGAGACGGTGGCCGTCAGCGTCCACTTCCAGGACCAGAATGACGTGGAGC
  TGAACAGGCTGAACTCTAACCTGCACGCCTGCGACTCGGGGGCCTCCATCCGATGGCAGG
  TGGTGGACAGGCGCATCCCACTCTATGCGAACCACAAGACCCTCCTCCAGAAGGCAGCCG
  CTGAGTTCGGGGCTCACTACTGACTGTGCCCTCAGGCTGGGCGGCTCCAGTCCATAGACG
  TTCCCCCCAGAAACCAGGGCTTCTCTCTCCTGAGCCTGGCCAGGACTCAGGCTGTTCCTG
  GGCCCTGCACATGATGGGGTTTGGTGGACCCAGTGCCCCTCACGGCTGCCGCAAGTCTGC
  TGCAGATGACCTCATGAACTGGAAGGGGTCAAGGTGACCCGGGAGGAGAGCTCAAGACAG
  GGCACAGGCTACTCAGAGCTGAGGGGCCCCTGGGACCCTTGGCCATCAGGCGAGGGGCTG
  GGCCTGTGCAGCTGGGCCCTTGGCCAGAGTCCACTCCCTTCCTGGCTGTGTCACCCCGAG
  CAGCTCATCCACCATGGAGGTCATTGGCCTGAGGCAAGTTCCCCGGAGAGTCGGGGTCCC
  CTGTGGCCCCCTCAGGCCTATGTCTGTGAGGAAGGGGCCCTGCCACTCTCCCCAAGAGGG
  CCTCCATGTTTCGAGGTGCCTCAACATGGAGCCTTGCCTGGCCTGGGCTAGGGGCACTGT
  CTGAACTCCTGACTGTCAGGATAAACTCCGTGGGGGTACAGGAGCCCAGACAAAGCCCAG
  GCCTGTCAAGAGACGCAGAGGGCCCCTGCCAGGGTTGGCCCCAGGGACCCTGGGACGAGG
  CTGCAGAAGCTCTCCCTCCCTACTCCCTGGGAGCCACGTGCTGGCCATGTGGCCAGGGAC
  GGCATGAGCAGGAGGCGGGGACGTGGGGGCCTTCTGGTTTGGTGTCAACAGCTCACAGGA
  GCGTGAACCATGAGGGCCCTCAGGAGGGGAACGTGGTAAAACCCAAGACATTAAATCTGC
  CATCTCAGGCCTGGCTGGCTCTTCTGTGCTTTCCACAAATAAAGTTCCTGACACGTCCAG
  GGCCAGGGGCTGTGTGACGGCTGCCTGAAGTTCTCCTCGATCCCCCGGTGAGCTTCCTGC
  AGCCTGTGGATGTCCTGCAGCCCCTCAGCCCTACCCCCAAGTTTTTCCTCTGAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >Reverse primer walk for NM_003307 unedited
  NGGGGCGATCGCCTTNCTTGTGACTGCTGCTCAGNCTGNAGATCCCGCACCGCCTCGCCT
  ACCTGCTTCATGACGCCGGTGTGGGACCCCCCTGTGATGATCCAGGCCCCTGTGGTCTGA
  GCCACCTTGACCAGGCCTCTGCGGAAAATGCTCTTCAGCCGCGGCTTCATGTTGAAGTTC
  TTGGCCCCCCCGGTCACCGAGATCAAGAGATTGGGGACGTCCAGCCCCCAGTGCTGGGTC
  ATGAGGTGGTAGATCACGCTGGAGGGCGTGTCCTGGGAGACTCGGACGTACTTTTTCACC
  TTCTGGCTCAGGCCCGTGAAGACGATGTCGCCAAAGGCATCGGTTGGCATCTCCTGGACA
  TGTTTCTTTGGGTCCCACTGTGTGCCCTGGAAGGTGTGGGGCTTGGTAGCCTCCTCCAAG
  TGCTGCTCATGCGTGTAGCCACACTGACACACCACCTTCCCAGCATCAGACAGTTTGGAA
  CTTTCCACAAAATACACGCATTCTTTCTTCTTGATGTTTTCAGGAATCCACGAACTGAGG
  CTTTCTTGCTTGTCATTGTTGNCCGAAGGGCACTGTAGCCTCCAGCTCTTGAAGAGGCTG
  CTGTTGCTGCGCCGGAGATTGGAGACCATCCCCAGGTCAGTGACCCTTCTGGGCAGTCCC
  TCAAAGCCCTCCTCCTGCTCCGAGCCAGCTTTTCCTCAGGCTGANGGCTCCATTCTGAGA
  CCCCCACGCCAGCTGCAACCAGGCCTGCTGCCCCTCAGACAGTCCTCTCTCCAGCTCGCT
  ACAAGGGCGAATTCGCGGCCGCTGCANAAGAAACAGTAGCTTGTATTCTATAGTGTCACC
  CTAATGAGCTCTGCTTATATAGACCTNCCACCGTAACACGCCTACCGGCCATTTNGCGTC
  ACGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_003307 unedited
  AGNAAAGCACTGGGGNAGGGTCACAGGGATGCCACCCGGGCTCTGTTCAGGAAACAGCTA
  TGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTC
  AAAGGAAAAACTTGGGGGTAGGGCTGAGGGGCTGCAGGACATCCACAGGCTGCAGGAAGC
  TCACCGGGGGATCGAGGAGAACTTCAGGCAGCCGTCACACAGCCCCTGGCCCTGGACGTG
  TCAGGAACTTTATTTGTGGAAAGCACAGAAGAGCCAGCCAGGCCTGAGATGGCAGATTTA
  ATGTCTTGGGTTTTACCACGTTCCCCTCCTGAGGGCCCTCATGGTTCACGCTCCTGTGAG
  CTGTTGACACCAAACCAGAAGGCCCCCACGTCCCCGCCTCCTGCTCATGCCGTCCCTGGC
  CACATGGCCAGCACGTGGCTCCCAAGGAGTAGGGAGGGAGAGCTTCTTGCACCTCGTTCC
  CAGGTCCCTGGGGCCCACCCTTGCAGGGGCCCCTCTGCGTCTCNTGACAGGGCCTGGCTT
  TTTGTCTGGGCTCTGGTCCCCCACGGAGTTTATTCCTGAACGTCAAGAATTCAAAACGTG
  CCCCTTGCCCCAGCCAAGCAAGGCTTCATGTTGAGGCACCTTCAAACATTGGAGCCCTCC
  TGGGGAAAGTGGCAGGCCCCCTCCCTACAGACTAAGCCTGTAAGGGGCCACAGGGGACCC
  CGACTTTTCGGGGAACTTGCCTTAGCCGATTACCTTCATGGGTGGATGAACTGGTCTGGG
  TTGCCCCACCCCGAAGGGGATGGACTCTTGGCCAAGGGCCCAACTTGCCAGG
  
• Restriction Sites: Please inquire
• ACCN: NM_003307
• Insert Size: 5600 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substituion of 1 aa.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003307.3, NP_003298.1
• RefSeq Size: 5876 bp
• RefSeq ORF: 4512 bp
• Locus ID: 7226
• UniProt ID: O94759
• Cytogenetics: 21q22.3
• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
• Gene Summary: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
  Transcript Variant: This variant (1) encodes isoform 1.