SHMT1 (NM_148918) Human Untagged Clone
SHMT1 (untagged)-Human serine hydroxymethyltransferase 1 (soluble) (SHMT1), nuclear gene encoding mitochondrial protein, transcript variant 2
|Product Name||SHMT1 (NM_148918) Human Untagged Clone|
Fully Sequenced ORF
>NCBI ORF sequence for NM_148918, the custom clone sequence may differ by one or more nucleotides
|ORF Size||1335 bp|
|OTI Disclaimer||Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).|
|OTI Annotation||The ORF of this clone has been fully sequenced and found to be a perfect match to NM_148918.1.|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Pathways||Glycine, serine and threonine metabolism, Cyanoamino acid metabolism, One carbon pool by folate, Methane metabolism, Metabolic pathways|
|Gene Summary||This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
|cDNA Clone Resources|