BMPR1A (NM_004329) Human Untagged Clone

CAT#: SC127222

BMPR1A (untagged)-Human bone morphogenetic protein receptor, type IA (BMPR1A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BMPR1A
• Synonyms: 10q23del; ACVRLK3; ALK3; CD292; SKR5
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_004329 edited
  AATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCG
  TCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTCCGTC
  CGCGCGCGGCGAAGATCGCACGGCCCGATCGAGGGGCGACCGGGTCGGGGCCGCTGCACG
  CCAAGGGCGAAGGCCGATTCGGGCCCCACTTCGCCCCGGCGGCTCGCCGCGCCCACCCGC
  TCCGCGCCGAGGGCTGGAGGATGCGTTCCCTGGGGTCCGGACTTATGAAAATATGCATCA
  GTTTAATACTGTCTTGGAATTCATGAGATGGAAGCATAGGTCAAAGCTGTTTGGAGAAAA
  TCAGAAGTACAGTTTTATCTAGCCACATCTTGGAGGAGTCGTAAGAAAGCAGTGGGAGTT
  GAAGTCATTGTCAAGTGCTTGCGATCTTTTACAAGAAAATCTCACTGAATGATAGTCATT
  TAAATTGGTGAAGTAGCAAGACCAATTATTAAAGGTGACAGTACACAGGAAACATTACAA
  TTGAACAATGCCTCAGCTATACATTTACATCAGATTATTGGGAGCCTATTTGTTCATCAT
  TTCTCGTGTTCAAGGACAGAATCTGGATAGTATGCTTCATGGCACTGGGATGAAATCAGA
  CTCCGACCAGAAAAAGTCAGAAAATGGAGTAACCTTAGCACCAGAGGATACCTTGCCTTT
  TTTAAAGTGCTATTGCTCAGGGCACTGTCCAGATGATGCTATTAATAACACATGCATAAC
  TAATGGACATTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTC
  AGGGTGTATGAAATATGAAGGATCTGATTTTCAGTGCAAAGATTCTCCAAAAGCCCAGCT
  ACGCCGGACAATAGAATGTTGTCGGACCAATTTATGTAACCAGTATTTGCAACCCACACT
  GCCCCCTGTTGTCATAGGTCCGTTTTTTGATGGCAGCATTCGATGGCTGGTTTTGCTCAT
  TTCTATGGCTGTCTGCATAATTGCTATGATCATCTTCTCCAGCTGCTTTTGTTACAAACA
  TTATTGCAAGAGCATCTCAAGCAGACGTCGTTACAATCGTGATTTGGAACAGGATGAAGC
  ATTTATTCCAGTTGGAGAATCACTAAAAGACCTTATTGACCAGTCACAAAGTTCTGGTAG
  TGGGTCTGGACTACCTTTATTGGTTCAGCGAACTATTGCCAAACAGATTCAGATGGTCCG
  GCAAGTTGGTAAAGGCCGATATGGAGAAGTATGGATGGGCAAATGGCGTGGCGAAAAAGT
  GGCGGTGAAAGTATTCTTTACCACTGAAGAAGCCAGCTGGTTTCGAGAAACAGAAATCTA
  CCAAACTGTGCTAATGCGCCATGAAAACATACTTGGTTTCATAGCGGCAGACATTAAAGG
  TACAGGTTCCTGGACTCAGCTCTATTTGATTACTGATTACCATGAAAATGGATCTCTCTA
  TGACTTCCTGAAATGTGCTACACTGGACACCAGAGCCCTGCTTAAATTGGCTTATTCAGC
  TGCCTGTGGTCTGTGCCACCTGCACACAGAAATTTATGGCACCCAAGGAAAGCCCGCAAT
  TGCTCATCGAGACCTAAAGAGCAAAAACATCCTCATCAAGAAAAATGGGAGTTGCTGCAT
  TGCTGACCTGGGCCTTGCTGTTAAATTCAACAGTGACACAAATGAAGTTGATGTGCCCTT
  GAATACCAGGGTGGGCACCAAACGCTACATGGCTCCCGAAGTGCTGGACGAAAGCCTGAA
  CAAAAACCACTTCCAGCCCTACATCATGGCTGACATCTACAGCTTCGGCCTAATCATTTG
  GGAGATGGCTCGTCGTTGTATCACAGGAGGGATCGTGGAAGAATACCAATTGCCATATTA
  CAACATGGTACCGAGTGATCCGTCATACGAAGATATGCGTGAGGTTGTGTGTGTCAAACG
  TTTGCGGCCAATTGTGTCTAATCGGTGGAACAGTGATGAATGTCTACGAGCAGTTTTGAA
  GCTAATGTCAGAATGCTGGGCCCACAATCCAGCCTCCAGACTCACAGCATTGAGAATTAA
  GAAGACGCTTGCCAAGATGGTTGAATCCCAAGATGTAAAAATCTGATGGTTAAACCATCG
  GAGGAGAAACTCTAGACTGCAAGAACTGTTTTTACCCATGGCATGGGTGGAATTAGAGTG
  GAATAAGGATGTTAACTTGGTTCTCAGACTCTTTCTTCACTACGTGTTCACAGGCTGCTA
  ATATTAAACCTTTCAGTACTCTTATTAGGATACAAGCTGGGAACTTCTAAACACTTCATT
  CTTTATATATGGACAGCTTTATTTTAAATGTGGTTTTTGATGCCTTTTTTTAAGTGGGTT
  TTTATGAACTGCATCAAGACTTCAATCCTGATTAGTGTCTCCAGTCAAGCTCTGGGTACT
  GAATTGCCTGTTCATAAAACGGTGCTTTCTGTGAAAGCCTTAAGAAGATAAATGAGCGCA
  GCAGAGATGGAGAAATAGACTTTGCCTTTTACCTGAGACATTCAGTTCGTTTGTATTCTA
  CCTTTGTAAAACAGCCTATAGATGATGATGTGTTTGGGATACTGCTTATTTTATGATAGT
  TTGTCCTGTGTCCTTAGTGATGTGTGTGTGTCTCCATGCACATGCACGCCGGGATTCCTC
  TGCTGCCATTTGAATTAGAAGAAAATAATTTATATGCATGCACAGGAAGATATTGGTGGC
  CGGTGGTTTTGTGCTTTAAAAATGCAATATCTGACCAAGATTCGCCAATCTCATACAAGC
  CATTTACTTTGCAAGTGAGATAGCTTCCCCACCAGCTTTATTTTTTAACATGAAAGCTGA
  TGCCAAGGCCAAAAGAAGTTTAAAGCATCTGTAAATTTGGACTGTTTTCCTTCAACCACC
  ATTTTTTTTGTGGTTATTATTTTTGTCACGGAAAGCATCCTCTCCAAAGTTGGAGCTTCT
  ATTGCCATGAACCATGCTTACAAAGAAAGCACTTCTTATTGAAGTGAATTCCTGCATTTG
  ATAGCAATGTAAGTGCCTATAACCATGTTCTATATTCTTTATTCTCAGTAACTTTTAAAA
  GGGAAGTTATTTATATTTTGTGTATAATGTGCTTTATTTGCAAATCACCCACTCCTTTAC
  AACCATACTTTATATATGTACATACATTCATACTGTAGAAACCAGCTCATGTGTACCTCA
  TATCCCATCCTTAAGAGAAGAAATGTTATAAAGTAGAACTAAATATAAATTTTCAGAATT
  AATGCATTCAAAGTAATATATCAAATCCAGGACTTTGTTAACTTCAGGTAAAAACTTCAT
  TAGGGTAATATCATCTCAATTTTTTCAAATGAAAGGATTCTCTAATTAGAAATTTATATG
  TCAGAGCTGTTATAAATTTATCAACTGTCAAATATGTTCTGGACAGCTAAATCATTTGAG
  ATTTTTGGTTTTTTGATTTCTATTCCCTAACTTGTGAAGACAATGAAAAATCAGGCAGAA
  ATATTTAGTATCTAGTCAGTATCTGTAGCTACACTGTATAACTGTTCTTCAATAAAATGG
  TTCATATTTTATAGAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004329 unedited
  TGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTCCGTCCGCGCGCGG
  CGAAGATCGCACGGCCCGATCGAGGGGCGACCGGGTCGGGGCCGCTGCACGCCAAGGGCG
  AAGGCCGATTCGGGCCCCACTTCGCCCCGGCGGCTCGCCGCGCCCACCCGCTCCGCGCCG
  AGGGCTGGAGGATGCGTTCCCTGGGGTCCGGACTTATGAAAATATGCATCAGTTTAATAC
  TGTCTTGGAATTCATGAGATGGAAGCATAGGTCAAAGCTGTTTGGAGAAAATCAGAAGTA
  CAGTTTTATCTAGCCACATCTTGGAGGAGTCGTAAGAAAGCAGTGGGAGTTGAAGTCATT
  GTCAAGTGCTTGCGATCTTTTACAAGAAAATCTCACTGAATGATAGTCATTTAAATTGGT
  GAAGTAGCAAGACCAATTATTAAAGGTGACAGTACACAGGAAACATTACAATTGAACAAT
  GCCTCAGCTATACATTTACATCAGATTATTGGGAGCCTATTTGTTCATCATTTCTCGTGT
  TCAAGGACAGAATCTGGATAGTATGCTTCATGGCACTGGGATGAAATCAGACTCCGACCA
  GAAAAAGTCAGAAAATGGAGTAACCTTAGCACCAGAGGATACCTTGCCTTTTTTAAAGTG
  CTATTGCTCAGGGCACTGTCCAGATGATGCTATTAATAACACATGCATAACTAATGGACA
  TTGCTTTGCCATCATAGAAGAAGATGACCAGGGAGAAACCACATTAGCTTCAGGGTGTAT
  GAAATATGAAGGATCTGATTTTCAGTGCAAAGATTCTNCANAAGCCCAGCTACGCCCGGA
  CATAGAATGTTGTCGGACCAATTTATGTNACCAGTATTTGCAACCACACTNNGCCCCTGT
  GTCAATAGGTCCCGTTTTTGATGCAGCATCGAATGGCTGGTC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004329 unedited
  GCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTCTATAAAATATGAACCATT
  TTATTGAAGAACAGTTATACAGTGTAGCTACAGATACTGACTAGATACTAAATATTTCTG
  CCTGATTTTTCATTGTCTTCACAAGTTAGGGAATAGAAATCAAAAAACCAAAAATCTCAA
  ATGATTTAGCTGTCCAGAACATATTTGACAGTTGATAAATTTATAACAGCTCTGACATAT
  AAATTTCTAATTAGAGAATCCTTTCATTTGAAAAAATTGAGATGATATTACCCTAATGAA
  GTTTTTACCTGAAGTTAACAAAGTCCTGGATTTGATATATTACTTTGAATGCATTAATTC
  TGAAAATTTATATTTAGTTCTACTTTATAACATTTCTTCTCTTAAGGATGGGATATGAGG
  TACACATGAGCTGGTTTCTACAGTATGAATGTATGTACATATATAAAGTATGGTTGTAAA
  GGAGTGGGTGATTTGCAAATAAAGCACATTATACACAAAATATAAATAACCTTCCCTTTT
  AAAAGTTACTGAGAATAAAGAATATAGAACATGGTTATAGGCACTTACATTGCTATCAAA
  TGCAGGAATTCACTTCAATAAGAGTGCTTTCTTTGTAGCATGTTCATGGCATAGAAGCTC
  ACTTTGGAGAGATGCTTTCGTGACAAAAATATACCACAAAAAAATGTGGGTTGAGGAAAC
  AGNTCAAATTACAGATGCTTTAAACTTCTTTGGGNCTTGGCATCAGCTTTCATGGTAAAA
  ATAAAGCTGGTGGGGAAGCTATCTACTTGCAAGTAAATGGCTTGATGAAATTGCGAATCT
  TGTCAGATTTGCATTTTTAAGCACAAACCCCGGCACCAATATTNCGTGGCAGCATATAAT
  TTTTTCTCTATTCAATGCAACAAGAATCCCGGTGCTTTGCCTGGGACCCCCCCTTCCTAG
  CCCCGACAAACTTCTAAATAGNCGTTCCCACCCATATCTTTAGCCGGTTCAAGGTAAATC
  ACAACTGAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004329
• Insert Size: 3370 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004329.2, NP_004320.2
• RefSeq Size: 3631 bp
• RefSeq ORF: 1599 bp
• Locus ID: 657
• UniProt ID: P36894
• Cytogenetics: 10q23.2
• Domains: Activin_recp, pkinase, TyrKc, S_TKc, GS
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
• Gene Summary: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]