Activin Receptor Type IIA (ACVR2A) (NM_001616) Human Untagged Clone

CAT#: SC125520

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ACVR2A (untagged)-Human activin A receptor, type IIA (ACVR2A)


  View "NM_001616" in other vectors (10)

USD 310.00


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Size
    • 10 ug


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Specifications

Product Data
Product Name Activin Receptor Type IIA (ACVR2A) (NM_001616) Human Untagged Clone
Type Human Untagged Clone
Tag Tag Free
Symbol ACVR2A
Synonyms ACTRII; ACVR2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Cell Selection None
Sequence Data
>OriGene ORF within SC125520 sequence for NM_001616 edited (data generated by NextGen Sequencing)
ATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGGTGCT
ATACTTGGTAGATCAGAAACTCAGGAGTGTCTTTTCTTTAATGCTAATTGGGAAAAAGAC
AGAACCAATCAAACTGGTGTTGAACCGTGTTATGGTGACAAAGATAAACGGCGGCATTGT
TTTGCTACCTGGAAGAATATTTCTGGTTCCATTGAAATAGTGAAACAAGGTTGTTGGCTG
GATGATATCAACTGCTATGACAGGACTGATTGTGTAGAAAAAAAAGACAGCCCTGAAGTA
TATTTTTGTTGCTGTGAGGGCAATATGTGTAATGAAAAGTTTTCTTATTTTCCAGAGATG
GAAGTCACACAGCCCACTTCAAATCCAGTTACACCTAAGCCACCCTATTACAACATCCTG
CTCTATTCCTTGGTGCCACTTATGTTAATTGCGGGGATTGTCATTTGTGCATTTTGGGTG
TACAGGCATCACAAGATGGCCTACCCTCCTGTACTTGTTCCAACTCAAGACCCAGGACCA
CCCCCACCTTCTCCATTACTAGGTTTGAAACCACTGCAGTTATTAGAAGTGAAAGCAAGG
GGAAGATTTGGTTGTGTCTGGAAAGCCCAGTTGCTTAACGAATATGTGGCTGTCAAAATA
TTTCCAATACAGGACAAACAGTCATGGCAAAATGAATACGAAGTCTACAGTTTGCCTGGA
ATGAAGCATGAGAACATATTACAGTTCATTGGTGCAGAAAAACGAGGCACCAGTGTTGAT
GTGGATCTTTGGCTGATCACAGCATTTCATGAAAAGGGTTCACTATCAGACTTTCTTAAG
GCTAATGTGGTCTCTTGGAATGAACTGTGTCATATTGCAGAAACCATGGCTAGAGGATTG
GCATATTTACATGAGGATATACCTGGCCTAAAAGATGGCCACAAACCTGCCATATCTCAC
AGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAACCTGACAGCTTGCATTGCTGAC
TTTGGGTTGGCCTTAAAATTTGAGGCTGGCAAGTCTGCAGGCGATACCCATGGACAGGTT
GGTACCCGGAGGTACATGGCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGAT
GCATTTTTGAGGATAGATATGTATGCCATGGGATTAGTCCTATGGGAACTGGCTTCTCGC
TGTACTGCTGCAGATGGACCTGTAGATGAATACATGTTGCCATTTGAGGAGGAAATTGGC
CAGCATCCATCTCTTGAAGACATGCAGGAAGTTGTTGTGCATAAAAAAAAGAGGCCTGTT
TTAAGAGATTATTGGCAGAAACATGCTGGAATGGCAATGCTCTGTGAAACCATTGAAGAA
TGTTGGGATCACGACGCAGAAGCCAGGTTATCAGCTGGATGTGTAGGTGAAAGAATTACC
CAGATGCAGAGACTAACAAATATTATTACCACAGAGGACATTGTAACAGTGGTCACAATG
GTGACAAATGTTGACTTTCCTCCCAAAGAATCTAGTCTATGA

Clone variation with respect to NM_001616.3
354 g=>a
>OriGene 5' read for NM_001616 unedited
TTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGTTTTGTTCCGAGAGACG
GGAGAGGCGAGCGGAGCTGACAGTGATTTTGACAGTGATTTAAACCCGCTTTTGTTGTTG
TTGGCTTTTCGTTGTTTGGTTTTGTGTGTTGTGCGTGTGTGTGGCGGTTTTTCCCCCGTG
GTGCATTTTATTTTTTATCGTTGTGCTCTTTTTTTTCTTTTTTTTTTTTTTAACCCAGTG
AGCGNNNNTTTTTTTTTTTTTTTTTTTTTTTTTGGGGCTGGGCTTCCGAATATGTTTTAT
GACGGTTGATTTTACACCAGGAGGTTTGTCTCCGAGGAAAACCCAGGGAACTGGTTTTTT
AGCGAGAACTTCCTCCGGATTCCCCGGCGCCTCGGGAAAATGGGAGCTGCTGCAAAGTTG
GCGTTTGCCGTCTTTTTTATCTCCTGTTCTTCAGGGGCTATACTTGGTAAATCAAAAACT
CAGGAGGGGCTTTTCTTTAATGCTAATTGGGAAAAAGACAGAACCCATCAAACTGGTGTT
GAACCGTGTTATGGTGACAAAAATAAACGGCGGCTTTGTTTTGCTACCTGGAAGAATATT
TCTGGTTCCATTGAAATAGGGAAACAAGGGTTGTTTGGCTGGATGATATCAACTGCTATT
ACAGGACTGATTGTGTAAAAAAAAAAACAGCCCTGAAGTTATTTTTTGTTGCTGGGAGGG
CATATTTGAATGAAAAAGTTTTTTATTTTCCAAATTGGAGTCCCCACCCCCTTTAATTCA
GTTCACCTAACCCCCCTTACACAATCCTGTTTATTCCTTGGGCCCCTATGGTATTGGGGG
GGGATTGGCTTTTGGCCTTTTGGGGGGGCCAGCTTCACAAAATGGCTACCTCCTGGCCTG
TTCCACTAAGAACAGAACCCCCCCCTTCATTATTTTGGG
>OriGene 3' read for NM_001616 unedited
NNNNTTTTAGCTNTGNAACCGCGGCCGCAATCTAGNGATCGGTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTAAATTTCATGATATGATTCTATTTTAAATTCCAAGGGGTTGGG
TTTTTTCCTGATTGTATTTTCAAAACATCACCATGAAAGATAGATAGTGCAAGTTCATGG
GACTAACAATCGTGAAGCACAGTCTCTTTTTCTGGAATTCACAAGGTACCTAGAATTCAA
ACAAGAATCACACATCACATGCTAAAAAAACTTCTAGCATCTAAAATACATACAAGAGCT
GTGCAGGGCATAAACTTCAAATAAAGCCGAACACTGGTTAATCCATCAGTCCTATGGCAA
GTTGATCATAAAGCATTCCTTACGCGGAGATCTGGGCAAGGTAAAGAGTATAAGTTAGAG
CAGCAGCAGTTCTGATGGGTATCAAAAAGGCAAAATACAAGACGAGTCATGAGGAGCACC
ATACACATGAGGAAAGAGTTATTTGGGGGGTCTCAGTTTGCCCCAAAATGGATCACCATT
TTTCTCATTCTTTGATCTTTTTTTTTTCCAGTATCTCTAGCTCAAACTTTCTGTTAACTT
GCCCACTCTGCACTGACTGTAAACCAAACACTAAATACCCTGCAAAAGAAAGTTTTAACA
AGACTAGGTATAAAGACAGGTAGTCACTGGAACCATTCTATTTTACTGCTTATAAAAAGT
TTTTCTATTAATAAAAAGTTCTCAAAAGATAACAGTTTTTAAATTGGTTAACCTCCGTTA
AATACAATACCCCGGGATTCTAAAAAATTTTTTCTACCTGGAAAACTTTTTTATGTGGAA
AAACTGGGTTTAAAAATTTATTTCTTGGCCTCCCTAACCCCAAACTTTCTATAAATTCCA
Restriction Sites NotI-NotI     
Tag Tag Free
ACCN NM_001616
ORF Size 1542 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reference Data
RefSeq NM_001616.3, NP_001607.1
RefSeq Size 5244
RefSeq ORF 1542
Locus ID 92
Cytogenetics 2q22.3-q23.1
Domains Activin_recp, pkinase, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
Gene Summary This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

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68 Mouse Clones