MRP1 (ABCC1) (NM_019902) Human Untagged Clone

CAT#: SC124215

ABCC1 (untagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 7

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MRP1
• Synonyms: MRP, ABCC, GS-X, MRP1, ABC29, DKFZp781G125, DKFZp686N04233
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC124215 sequence for NM_019902 edited (data generated by NextGen Sequencing)
  ATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCGACCCGCTCTGGGACTGGAATGTC
  ACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCTTTCAGAACACGGTCCTCGTGTGG
  GTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCTACTTCCTCTATCTCTCCCGACAT
  GACCGAGGCTACATTCAGATGACACCTCTCAACAAAACCAAAACTGCCTTGGGATTTTTG
  CTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTTTCTGGGAAAGAAGTCGGGGCATA
  TTCCTGGCCCCAGTGTTTCTGGTCAGCCCAACTCTCTTGGGCATCACCATGCTGCTTGCT
  ACCTTTTTAATTCAGCTGGAGAGGAGGAAGGGAGTTCAGTCTTCAGGGATCATGCTCACT
  TTCTGGCTGGTAGCCCTAGTGTGTGCCCTAGCCATCCTGAGATCCAAAATTATGACAGCC
  TTAAAAGAGGATGCCCAGGTGGACCTGTTTCGTGACATCACTTTCTACGTCTACTTTTCC
  CTCTTACTCATTCAGCTCGTCTTGTCCTGTTTCTCAGATCGCTCACCCCTGTTCTCGGAA
  ACCATCCACGACCCTAATCCCTGCCCAGAGTCCAGCGCTTCCTTCCTGTCGAGGATCACC
  TTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACCGCCAGCCCCTGGAGGGCAGTGAC
  CTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAGTCGTGCCTGTTTTGGTAAAGAAC
  TGGAAGAAGGAATGCGCCAAGACTAGGAAGCAGCCGGTGAAGGTCGTGTACTCCTCCAAG
  GATCCTGCCCAGCCGAAAGAGAGTTCCAAGGTGGATGCGAATGAGGAGGTGGAGGCTTTG
  ATCGTCAAGTCCCCACAGAAGGAGTGGAACCCCTCTCTGTTTAAGGTGTTATACAAGACC
  TTTGGGCCCTACTTCCTCATGAGCTTCTTCTTCAAGGCCATCCACGACCTGATGATGTTT
  TCCGGGCCGCAGATCTTAAAGTTGCTCATCAAGTTCGTGAACGACACGAAGGCCCCAGAC
  TGGCAGGGCTACTTCTACACCGTGCTGCTGTTTGTCACTGCCTGCCTGCAGACCCTCGTG
  CTGCACCAGTACTTCCACATCTGCTTCGTCAGTGGCATGAGGATCAAGACCGCTGTCATT
  GGGGCTGTCTATCGGAAGGCCCTGGTGATCACCAATTCAGCCAGAAAATCCTCCACGGTC
  GGGGAGATTGTCAACCTCATGTCTGTGGACGCTCAGAGGTTCATGGACTTGGCCACGTAC
  ATTAACATGATCTGGTCAGCCCCCCTGCAAGTCATCCTTGCTCTCTACCTCCTGTGGCTG
  AATCTGGGCCCTTCCGTCCTGGCTGGAGTGGCGGTGATGGTCCTCATGGTGCCCGTCAAT
  GCTGTGATGGCGATGAAGACCAAGACGTATCAGGTGGCCCACATGAAGAGCAAAGACAAT
  CGGATCAAGCTGATGAACGAAATTCTCAATGGGATCAAAGTGCTAAAGCTTTATGCCTGG
  GAGCTGGCATTCAAGGACAAGGTGCTGGCCATCAGGCAGGAGGAGCTGAAGGTGCTGAAG
  AAGTCTGCCTACCTGTCAGCCGTGGGCACCTTCACCTGGGTCTGCACGCCCTTTCTGGCG
  AGTGTCTCCCTCAAACGCCTGAGGATCTTTCTCTCCCATGAGGAGCTGGAACCTGACAGC
  ATCGAGCGACGGCCTGTCAAAGACGGCGGGGGCACGAACAGCATCACCGTGAGGAATGCC
  ACATTCACCTGGGCCAGGAGCGACCCTCCCACACTGAATGGCATCACCTTCTCCATCCCC
  GAAGGTGCTTTGGTGGCCGTGGTGGGCCAGGTGGGCTGCGGAAAGTCGTCCCTGCTCTCA
  GCCCTCTTGGCTGAGATGGACAAAGTGGAGGGGCACGTGGCTATCAAGGGCTCCGTGGCC
  TATGTGCCACAGCAGGCCTGGATTCAGAATGATTCTCTCCGAGAAAACATCCTTTTTGGA
  TGTCAGCTGGAGGAACCATATTACAGGTCCGTGATACAGGCCTGTGCCCTCCTCCCAGAC
  CTGGAAATCCTGCCCAGTGGGGATCGGACAGAGATTGGCGAGAAGGGCGTGAACCTGTCT
  GGGGGCCAGAAGCAGCGCGTGAGCCTGGCCCGGGCCGTGTACTCCAACGCTGACATTTAC
  CTCTTCGATGATCCCCTCTCAGCAGTGGATGCCCATGTGGGAAAACACATCTTTGAAAAT
  GTGATTGGCCCCAAGGGGATGCTGAAGAACAAGACGCGGATCTTGGTCACGCACAGCATG
  AGCTACTTGCCGCAGGTGGACGTCATCATCGTCATGAGTGGCGGCAAGATCTCTGAGATG
  GGCTCCTACCAGGAGCTGCTGGCTCGAGACGGCGCCTTCGCTGAGTTCCTGCGTACCTAT
  GCCAGCACAGAGCAGGAGCAGGATGCAGAGGAGAACGGGGTCACGGGCGTCAGCGGTCCA
  GGGAAGGAAGCAAAGCAAATGGAGAATGGCATGCTGGTGACGGACAGTGCAGGGAAGCAA
  CTGCAGAGACAGCTCAGCAGCTCCTCCTCCTATAGTGGGGACATCAGCAGGCACCACAAC
  AGCACCGCAGAACTGCAGAAAGCTGAGGCCAAGAAGGAGGAGACCTGGAAGCTGATGGAG
  GCTGACAAGGCGCAGACAGGGCAGGTCAAGCTTTCCGTGTACTGGGACTACATGAAGGCC
  ATCGGACTCTTCATCTCCTTCCTCAGCATCTTCCTTTTCATGTGTAACCATGTGTCCGCG
  CTGGCTTCCAACTATTGGCTCAGCCTCTGGACTGATGACCCCATCGTCAACGGGACTCAG
  GAGCACACGAAAGTCCGGCTGAGCGTCTATGGAGCCCTGGGCATTTCACAAGGGATCGCC
  GTGTTTGGCTACTCCATGGCCGTGTCCATCGGGGGGATCTTGGCTTCCCGCTGTCTGCAC
  GTGGACCTGCTGCACAGCATCCTGCGGTCACCCATGAGCTTCTTTGAGCGGACCCCCAGT
  GGGAACCTGGTGAACCGCTTCTCCAAGGAGCTGGACACAGTGGACTCCATGATCCCGGAG
  GTCATCAAGATGTTCATGGGCTCCCTGTTCAACGTCATTGGTGCCTGCATCGTTATCCTG
  CTGGCCACGCCCATCGCCGCCATCATCATCCCGCCCCTTGGCCTCATCTACTTCTTCGTC
  CAGAGGTTCTACGTGGCTTCCTCCCGGCAGCTGAAGCGCCTCGAGTCGGTCAGCCGCTCC
  CCGGTCTATTCCCATTTCAACGAGACCTTGCTGGGGGTCAGCGTCATTCGAGCCTTCGAG
  GAGCAGGAGCGCTTCATCCACCAGAGTGACCTGAAGGTGGACGAGAACCAGAAGGCCTAT
  TACCCCAGCATCGTGGCCAACAGGTGGCTGGCCGTGCGGCTGGAGTGTGTGGGCAACTGC
  ATCGTTCTGTTTGCTGCCCTGTTTGCGGTGATCTCCAGGCACAGCCTCAGTGCTGGCTTG
  GTGGGCCTCTCAGTGTCTTACTCATTGCAGGTCACCACGTACTTGAACTGGCTGGTTCGG
  ATGTCATCTGAAATGGAAACCAACATCGTGGCCGTGGAGAGGCTCAAGGAGTATTCAGAG
  ACTGAGAAGGAGGCGCCCTGGCAAATCCAGGAGACAGCTCCGCCCAGCAGCTGGCCCCAG
  GTGGGCCGAGTGGAATTCCGGAACTACTGCCTGCGCTACCGAGAGGACCTGGACTTCGTT
  CTCAGGCACATCAATGTCACGATCAATGGGGGAGAAAAGGTCGGCATCGTGGGGCGGACG
  GGAGCTGGGAAGTCGTCCCTGACCCTGGGCTTATTTCGGATCAACGAGTCTGCCGAAGGA
  GAGATCATCATCGATGGCATCAACATCGCCAAGATCGGCCTGCACGACCTCCGCTTCAAG
  ATCACCATCATCCCCCAGGACCCTGTTTTGTTTTCGGGTTCCCTCCGAATGAACCTGGAC
  CCATTCAGCCAGTACTCGGATGAAGAAGTCTGGACGTCCCTGGAGCTGGCCCACCTGAAG
  GACTTCGTGTCAGCCCTTCCTGACAAGCTAGACCATGAATGTGCAGAAGGCGGGGAGAAC
  CTCAGTGTCGGGCAGCGCCAGCTTGTGTGCCTAGCCCGGGCCCTGCTGAGGAAGACGAAG
  ATCCTTGTGTTGGATGAGGCCACGGCAGCCGTGGACCTGGAAACGGACGACCTCATCCAG
  TCCACCATCCGGACACAGTTCGAGGACTGCACCGTCCTCACCATCGCCCACCGGCTCAAC
  ACCATCATGGACTACACAAGGGTGATCGTCTTGGACAAAGGAGAAATCCAGGAGTACGGC
  GCCCCATCGGACCTCCTGCAGCAGAGAGGTCTTTTCTACAGCATGGCCAAAGACGCCGGC
  TTGGTGTGA
  
  Clone variation with respect to NM_019902.1
  350 c=>t;825 t=>c;1062 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_019902 unedited
  ACCCCCGCCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCA
  GAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGA
  ATTCGGCACGAGGCCGGCATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCGACCCG
  CTCTGGGACTGGAATGTCACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCTTTCAG
  AACACGGTCCTCGTGTGGGTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCTACTTC
  CTCTATCTCTCCCGACATGACCGAGGCTACATTCAGATGACACCTCTCAACAAAACCAAA
  ACTGCCTTGGGATTTTTGCTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTTTCTGG
  GAAAGAAGTCGGGGCATATTCCTGGCCCCAGTGNTTCTGGTCAGCCCAACTCTCTTGGGC
  ATCACCATGCTGCTTGCTACCTTTTTAATTCCCCGGAGATCACCACCCCTTCCACTCTCC
  CCCTTTCCCTTCCTCCCCTCCTCCCGCNNNNNNNNNNCNNNCNNCNNCCCNNNNNNTCNN
  NNCCCNCCNNNCCCNCCCCCCCCCCCCNCCCCNCCCCCNCCTCCCCCCCCCCCCCCCCNN
  NCCNCCCCCCCCCCCCCCCCCCCCCCCNCCCCCCCCCCTCCCCCCNCNCCCCCCCCCCGC
  CCCCCCNCCCNCCCCCCCCCCNCNNCCCNTNCCCCCCNCTCNNCCCCCCCCCCNNCCCCC
  CCTCNCNCCCCACCCCCCCCCCNCCCCCCCCCCCCCCCCCCNCNCCNCCNNCCCCNCNCC
  CCCCNNNCCCCCCCCCCCNNCCCNNNCCCCCCCCCCCCCCCCCCCCNNCCCCCCCCCCCC
  CCCCCCCNCTTCTTTTCCTCCCCTTCTCTCCCTTCTTCCCCCCN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_019902
• Insert Size: 6000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_019902.1, NP_063957.1
• RefSeq Size: 5780 bp
• RefSeq ORF: 4449 bp
• Locus ID: 4363
• Cytogenetics: 16p13.11
• Domains: ABC_membrane, ABC_tran, AAA
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
  Transcript Variant: This variant (7) lacks exon 13, as compared to the predominant, full-length transcript variant 1. This results in a 49-amino acid in-frame deletion in the coding region.