Claudin 7 (CLDN7) (NM_001307) Human Untagged Clone

CAT#: SC121707

CLDN7 (untagged)-Human claudin 7 (CLDN7), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Claudin 7
• Synonyms: CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001307, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCAATTCGGGCCTGCAGTTGCTGGGCTTCTCCATGGCCCTGCTGGGCTGGGTGGGTCTGGTGGCCT
  GCACCGCCATCCCGCAGTGGCAGATGAGCTCCTATGCGGGTGACAACATCATCACGGCCCAGGCCATGTA
  CAAGGGGCTGTGGATGGACTGCGTCACGCAGAGCACGGGGATGATGAGCTGCAAAATGTACGACTCGGTG
  CTCGCCCTGTCCGCGGCCTTGCAGGCCACTCGAGCCCTAATGGTGGTCTCCCTGGTGCTGGGCTTCCTGG
  CCATGTTTGTGGCCACGATGGGCATGAAGTGCACGCGCTGTGGGGGAGACGACAAAGTGAAGAAGGCCCG
  TATAGCCATGGGTGGAGGCATAATTTTCATCGTGGCAGGTCTTGCCGCCTTGGTAGCTTGCTCCTGGTAT
  GGCCATCAGATTGTCACAGACTTTTATAACCCTTTGATCCCTACCAACATTAAGTATGAGTTTGGCCCTG
  CCATCTTTATTGGCTGGGCAGGGTCTGCCCTAGTCATCCTGGGAGGTGCACTGCTCTCCTGTTCCTGTCC
  TGGGAATGAGAGCAAGGCTGGGTACCGTGTACCCCGCTCTTACCCTAAGTCCAACTCTTCCAAGGAGTAT
  GTGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001307 unedited
  NGGTTCGGTATTTGTTAAACGACTCACTATAGGCGGCCGCGAATTGGCACGAGGCTGCTG
  GCTCACCTCCGAGCACCTCTGCTGCGCACCGGAGCCTCGGACCTACAGCCCAGGATACTT
  TGGGACTTGCCGGCGCTCAGAAACGCGCCCAGACGGCCCCTCCACCTTTTGTTTGCCTAG
  GGTCGCCGAGAGCGCCCGGAGGGAACCGCCTGGCCTTCGGGGACCACCAATTTTGTCTGG
  AACCACCCTCCCGGCGTATCCTACTCCCTGTGCCGCGAGGCCATCGCTTCACTGGAGGGG
  TCGATTTGTGTGTAGTTTGGTGACAAGATTTGCATTCACCTGGCCCAAACCCTTTTTGTC
  TCTTTGGGTGACCGGAAAACTCCACCTCAAGTTTTCTTTTGTGGGGCTGCCCCCCAAGTG
  TCGTTTGTTTTACTGTAGGGTCTCCCGCCCGGCGCCCCCAGTGTTTTCTGAGGGCGGAAA
  TGGCCAATTCGGGCCTGCAGTTGCTGGGCTTCTCCATGGCCCTGCTGGGCTGGGTGGGTC
  TGGTGGCCTGCACCGCCATCCCGCAGTGGCAGATGAGCTCCTATGCGGGTGACAACATCA
  TCACGGCCCAGGCCATGTACAAGGGGACTGTGGATGGACTGCGTCACGCAGAGCACGGGG
  ATGATGAGCTGCAAAATGTACGACTCGGTGCTCGCCCTGTCCGCGGCCTTGCAGGCCACT
  CGAGCCCTAATGGTGGTCTCCCTGGTGCTGGGCTTCCTGGCCATGTTTGTGGCCACGATG
  GGCATGAAGTGCACGCGCTGTGGGGGAGACCGACAAGTGAAGAACGCCCGTATAGCCATG
  GGTGGAGGCATAATTTTCATCGTGGCAAGTCTTGCCACCTTGGTAGCTTGCTCCTGGTAT
  GGCCATCAGATTGTCACAGACTTTTATGACCCTTTGATACCTACCAACATAA
  
• Restriction Sites: Please inquire
• ACCN: NM_001307
• Insert Size: 2000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001307.3, NP_001298.2
• RefSeq Size: 1332 bp
• RefSeq ORF: 636 bp
• Locus ID: 1366
• UniProt ID: O95471
• Cytogenetics: 17p13.1
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
• Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
  Transcript Variant: This variant (1) encodes the longer isoform (1).