Kappa Opioid Receptor(OPRK1) (NM_000912) Human Untagged Clone
OPRK1 (untagged)-Human opioid receptor, kappa 1 (OPRK1)
|Product Name||Kappa Opioid Receptor(OPRK1) (NM_000912) Human Untagged Clone|
|Synonyms||K-OR-1; KOR; KOR-1; OPRK|
Fully Sequenced ORF
>NCBI ORF sequence for NM_000912, the custom clone sequence may differ by one or more nucleotides
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000912 unedited
|ORF Size||4959 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at email@example.com or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||GPCR, Transmembrane, Druggable Genome|
|Protein Pathways||Neuroactive ligand-receptor interaction|
|Gene Summary||This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]
Transcript Variant: This variant (1) encodes the longer isoform (1).
|The use of this cDNA Clones has been cited in the following citations:|
Mechanism of direct Cav2.2 channel block by the ?-opioid receptor agonist U50488H.
,Berecki, G;Motin, L;Adams, DJ;,
Neuropharmacology May 2016,PubMed ID 27245500
|cDNA Clone Resources|