SCN1B (NM_001037) Human Untagged Clone

CAT#: SC119540

SCN1B (untagged)-Human sodium channel, voltage-gated, type I, beta (SCN1B), transcript variant a

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SCN1B
• Synonyms: ATFB13; BRGDA5; DEE52; EIEE52; GEFSP1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119540 sequence for NM_001037 edited (data generated by NextGen Sequencing)
  ATGGGGAGGCTGCTGGCCTTAGTGGTCGGCGCGGCACTGGTGTCCTCAGCCTGCGGGGGC
  TGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGC
  ATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGC
  CAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTG
  GAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGAC
  CTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAG
  TGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAG
  AAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAG
  ATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTAC
  TGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATAC
  CTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAG
  
  Clone variation with respect to NM_001037.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001037 unedited
  GGGGTTCCCATTTGTATACTATCATATAGGCGGCCGCGNAATTCGCACCAGGCAGCACGC
  GCCGCGCAGCCATGGGGAGGCTGCTGGCCTTAGTGGTCGGCGCGGCACTGGTGTCCTCAG
  CCTGCGGGGGCTGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCA
  AAATTCTTTGCATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGT
  GGACCTTCCGCCAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGG
  TGTTGCAGCTGGAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGG
  GCACCAAAGACCTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTCGG
  GCGACTACGAGTGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCA
  GCGTCGTCAAGAAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCA
  TCGTGTCTGAGATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAG
  AGATGATTTACTGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATG
  CCTNCGAATACCTGGCCATCACCTCTGAAAGCAAGAGGACTGCACGGGCGTCCAGGTGGC
  CGAATAGCCCTGGCCCTGGGCCCCGCCTCAGGGAGAAGCAGCCGTAAACGGGACTCTCCA
  GGCACGCCTGCCCCCACGTGGGGGTGCCCCCTCTGGCCCCAGAAAGCTCAGATCCTGCCG
  ACGAACCACTGGGGTGGGAGGGGCAAGGGGCTTGCTTCGAACCCCAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001037 unedited
  TTTTTTTTTTTTTTTTTCAAGTCCAAGAGTCTTTATTTCATGAACAAAACTACTTCTGTA
  AAGAGACGAGGCTGAATGGGCCCCTTTCTAGGTGGCCACAGTTCAAGGCTGGTGAGAGAG
  GGCGAGGTTGGGCCGGGGCAGGAGTGCATTACAGGGAGGGGGGACCCCAGGTCCAGCCGG
  AGGAAGCGGGAGGGGAAATGATGCCGGGGAGGGGGAGTCGGAGTGGGTCCCAGAACCCCC
  TGCCCCAAACTGCTCCAGCCCATCATCGCGACCCCTGCCGCCAGGCAGGGAGGAGGCGGG
  GAGGGGCTGGCCCCAGAAGTGCGTGTCTGAAGCGGCCAATGTGTGCAAATACCCAAGGAG
  GAGGGGTGCGGGGCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001037
• Insert Size: 1250 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001037.3, NP_001028.1
• RefSeq Size: 1521 bp
• RefSeq ORF: 657 bp
• Locus ID: 6324
• UniProt ID: Q07699
• Cytogenetics: 19q13.11
• Domains: ig
• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane
• Gene Summary: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
  Transcript Variant: This variant (a) represents the longer transcript but encodes the shorter isoform (a).